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    Dihydroindane carboxylic and cyclohexadiene acetic acids, esters and salts
    1.
    发明授权
    Dihydroindane carboxylic and cyclohexadiene acetic acids, esters and salts 失效
    二羟基二羧酸和环己酮乙酸，酯和盐

    公开(公告)号：US3852286A

    公开(公告)日：1974-12-03

    申请号：US33339573

    申请日：1973-02-16

    申请人： UPJOHN CO

    发明人： HALL C ,  WECHTER W

    IPC分类号： C07C57/62 ,  C07C63/50 ,  C07C69/76

    CPC分类号： C07C57/62 ,  Y10S514/916

    摘要： Fluoro, phenyl substituted cyclohexadiene compounds of FIGS. I and II

    wherein R is selected from the group consisting of hydrogen, alkyl of from one to three carbon atoms, inclusive, and a pharmaceutically acceptable metal or amine cation; X is selected from the group consisting of -CH3 and -CH2CH2with the proviso that -CH2 is attached to the 2 carbon atom of the cyclohexadiene, thereby forming an indane type compound and compositions thereof useful as an anti-inflammatory, analgesic, anti-pyretic, anti-allergic, anti-thrombolytic and inhibitor of prostaglandin synthesis.

    摘要翻译： 氟，苯基取代的环己二烯化合物 I和II，其中R选自氢，一至三个碳原子的烷基（包括端值）和药学上可接受的金属或胺阳离子; X选自-CH 3和-CH 2 CH 2 - ，条件是-CH 2连接到环己二烯的2个碳原子上，从而形成二氢化茚型化合物及其组合物，其用作抗炎，镇痛，抗氧化剂 - 抗老，抗过敏，抗血栓溶解和前列腺素合成抑制剂。