公开(公告)号：US11427582B2

公开(公告)日：2022-08-30

申请号：US17078739

申请日：2020-10-23

Applicant: UWM Research Foundation, Inc.

Inventor： James Cook ,  Daniel Knutson

IPC: C07D471/04 ,  C07D471/14 ,  A61K31/4745 ,  C07D498/14 ,  C07D495/14 ,  C07D491/147 ,  A61P25/18 ,  A61P25/24 ,  A61P27/16 ,  A61P25/06

Abstract: Provided herein are novel pyrazoloquinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis; depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.

公开(公告)号：US20210047322A1

公开(公告)日：2021-02-18

申请号：US17078739

申请日：2020-10-23

Applicant: UWM Research Foundation, Inc. ,  Medical University of Vienna ,  National Taiwan University ,  University of Belgrade - Faculty of Pharmacy

Inventor： Lih-Chu Chiou ,  James Cook ,  Margot Ernst ,  Pi-Chuan Fan ,  Daniel Knutson ,  Matheus Meirelles ,  Marko Mihovilovic ,  Werner Sieghart ,  Zdravko Varagic ,  Ranjit Verma ,  Laurin Wimmer ,  Christopher Witzigmann ,  David Chan Bodin Siebert ,  Miroslav M. Savic

IPC: C07D471/04 ,  C07D471/14 ,  A61K31/4745 ,  C07D498/14 ,  C07D495/14 ,  C07D491/147 ,  A61P25/18 ,  A61P25/24 ,  A61P27/16 ,  A61P25/06

Abstract: Provided herein are novel pyrazoloquinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis; depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.

公开(公告)号：US10259815B2

公开(公告)日：2019-04-16

申请号：US15560002

申请日：2016-03-18

Applicant: UWM Research Foundation, Inc.

Inventor： James Cook ,  Michael Ming-Jin Poe ,  Kashi Reddy Methuku ,  Guanguan Li

IPC: A61K31/5517 ,  A61P25/18 ,  C07D487/04

Abstract: Described herein are α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.

公开(公告)号：US20180065967A1

公开(公告)日：2018-03-08

申请号：US15560002

申请日：2016-03-18

Applicant: UWM Research Foundation, Inc.

Inventor： James Cook ,  Michael Ming-Jin Poe ,  Kashi Reddy Methuku ,  Guanguan Li

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Described herein are α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.

公开(公告)号：US20220079952A1

公开(公告)日：2022-03-17

申请号：US17612877

申请日：2020-05-22

Applicant: Emory University ,  UWM Research Foundation, Inc.

Inventor： Soma Sengupta ,  Daniel Pommeranz Krummel ,  Mohammad Khan ,  Tahseen Nasti ,  James Cook

IPC: A61K31/5513 ,  C07K16/28 ,  A61K39/395

Abstract: This disclosure relates to uses of radiation and benzodiazepines optionally in combination with other anticancer agents for treating cancer. In certain embodiments, this disclosure relates to methods of using radiation, benzodiazepines, and check point inhibitors in cancer therapies.

公开(公告)号：US20180134698A1

公开(公告)日：2018-05-17

申请号：US15578790

申请日：2016-06-03

Applicant: UWM Research Foundation, Inc. ,  Medical University of Vienna ,  National Taiwan University ,  University of Belgrade - Faculty of Pharmacy

Inventor： Lih-Chu Chiou ,  James Cook ,  Margot Ernst ,  Pi-Chuan Fan ,  Daniel Knutson ,  Matheus Meirelles ,  Marko Mihovilovic ,  Werner Sieghart ,  Zdravko Varagic ,  Ranjit Verma ,  Laurin Wimmer ,  Christopher Witzigmann ,  David Chan Bodin Siebert ,  Miroslav M. Savic

IPC: C07D471/04 ,  C07D471/14 ,  A61P25/18 ,  A61P25/24 ,  A61P25/06 ,  A61P27/16

CPC classification number: C07D471/04 ,  A61K31/4745 ,  A61P25/06 ,  A61P25/18 ,  A61P25/24 ,  A61P27/16 ,  C07D471/14 ,  C07D491/147 ,  C07D495/14 ,  C07D498/14

Abstract: Provided herein are novel pyrazolo-quinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis;depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.