公开(公告)号：US20190300534A1

公开(公告)日：2019-10-03

申请号：US16283926

申请日：2019-02-25

Applicant: UWM Research Foundation, Inc.

Inventor： James M. Cook ,  Michael Ming-Jin Poe ,  Kashi Reddy Methuku ,  Guanguan Li

IPC: C07D487/04

Abstract: Described herein are α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.

公开(公告)号：US10259815B2

公开(公告)日：2019-04-16

申请号：US15560002

申请日：2016-03-18

Applicant: UWM Research Foundation, Inc.

Inventor： James Cook ,  Michael Ming-Jin Poe ,  Kashi Reddy Methuku ,  Guanguan Li

IPC: A61K31/5517 ,  A61P25/18 ,  C07D487/04

Abstract: Described herein are α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.

公开(公告)号：US20180065967A1

公开(公告)日：2018-03-08

申请号：US15560002

申请日：2016-03-18

Applicant: UWM Research Foundation, Inc.

Inventor： James Cook ,  Michael Ming-Jin Poe ,  Kashi Reddy Methuku ,  Guanguan Li

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: Described herein are α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as α3 or α2 or α2/α3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.