公开(公告)号：US20240132955A1

公开(公告)日：2024-04-25

申请号：US18475532

申请日：2023-09-27

Applicant: Ultima Genomics, Inc.

Inventor： Linda LEE ,  Theo Nikiforov ,  Alexander Joseph Limardo ,  Maya H. Reamey ,  Steven Menchen ,  Gilad Almogy

IPC: C12Q1/6874 ,  C12Q1/6806 ,  G01N21/64

CPC classification number: C12Q1/6874 ,  C12Q1/6806 ,  G01N21/6486

Abstract: Provided herein are reagents, compositions, and methods for sequencing nucleic acids. Among the reagents disclosed are nucleotides labeled with cleavable linkers. Certain linkers are configured to undergo immolation reactions following cleavage, which can generate scars with enhanced properties for nucleic acid sequencing and synthesis. The present disclosure also provides reagents, compositions, and methods for capping scars generated through linker cleavage, which can alter scar properties, and in some cases can increase the rate and accuracy of nucleotide incorporations during polymerization.