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公开(公告)号:US11123351B2
公开(公告)日:2021-09-21
申请号:US16797426
申请日:2020-02-21
IPC分类号: A61K31/568 , A61P1/16 , A61K9/48 , A61K47/14 , A61K31/7016 , A61K31/437
摘要: The present invention is directed to a novel pharmaceutical formulation comprising 3α-ethynyl-3β-hydroxyandrostan-17-one oxime in an amount of 0.1-10% by weight of the total weight of the composition; and a vehicle comprising (a) 45-100% of a monoester; (b) optionally up to 51% of a diester; and (c) optionally up to about 10% of a triester. Also claimed is a method for the treatment of medical conditions such as hypersomnia and hepatic encephalopathy by the use of a pharmaceutical formulation as claimed.
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公开(公告)号:US20200297737A1
公开(公告)日:2020-09-24
申请号:US16797426
申请日:2020-02-21
IPC分类号: A61K31/568 , A61P1/16 , A61K9/48 , A61K47/14
摘要: The present invention is directed to a novel pharmaceutical formulation comprising 3α-ethynyl-3β-hydroxyandrostan-17-one oxime in an amount of 0.1-10% by weight of the total weight of the composition; and a vehicle comprising (a) 45-100% of a monoester; (b) optionally up to 51% of a diester; and (c) optionally up to about 10% of a triester. Also claimed is a method for the treatment of medical conditions such as hypersomnia and hepatic encephalopathy by the use of a pharmaceutical formulation as claimed.
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公开(公告)号:US10603326B2
公开(公告)日:2020-03-31
申请号:US16450620
申请日:2019-06-24
IPC分类号: A61K31/568 , A61P1/16 , A61K9/48 , A61K47/14 , A61K31/437 , A61K31/7016
摘要: The present invention is directed to a novel pharmaceutical formulation comprising 3α-ethynyl-3β-hydroxyandrostan-17-one oxime in an amount of 0.1-10% by weight of the total weight of the composition; and a vehicle comprising (a) 45-100% of a monoester; (b) optionally up to 51% of a diester; and (c) optionally up to about 10% of a triester. Also claimed is a method for the treatment of medical conditions such as hypersomnia and hepathic encephalopathy by the use of a pharmaceutical formulation as claimed.
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公开(公告)号:US10278977B2
公开(公告)日:2019-05-07
申请号:US15613539
申请日:2017-06-05
IPC分类号: A61K31/568 , A61K31/04 , A61K31/015
摘要: There is provided a method of treatment of hypersomnolence comprising administering the steroidal compound 3α-ethynyl-3β-hydroxy-5α-androstan-17-one oxime, or a pharmaceutically acceptable salt thereof, to a subject in need of such treatment.
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公开(公告)号:US20170348323A1
公开(公告)日:2017-12-07
申请号:US15613539
申请日:2017-06-05
IPC分类号: A61K31/568 , A61K31/015 , A61K31/04 , C07C205/05
CPC分类号: A61K31/568 , A61K31/015 , A61K31/04
摘要: There is provided a method of treatment of hypersomnolence comprising administering the steroidal compound 3α-ethynyl-3β-hydroxy-5α-androstan-17-one oxime, or a pharmaceutically acceptable salt thereof, to a subject in need of such treatment.
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