-
1.发明申请公开(公告)号：US20170369522A1
公开(公告)日：2017-12-28
申请号：US15542800
申请日：2016-01-11
CPC分类号： C07J41/005 , A61K31/57 , A61K45/06 , Y02A50/463
摘要： The invention relates to 3α-ethynyl, 3β-hydroxy, 5α-pregnan-20-oxime or a pharmaceutically acceptable salt thereof, which compounds and/or salts are useful as modulators of the mammal brain excitability via the gamma-5 aminobutyric acid receptor-chloride ionophore (GABAA-R) complex and in the treatment of disorders such as hepatic encephalopathy, Down's syndrome and Alzheimer's disease.
-
2.发明申请STEROID COMPOUND FOR USE IN THE TREATMENT OF HEPATIC ENCEPHALOPATHY 有权STEROID化合物用于治疗HEPATIC ENCEPHALOPATHYY公开(公告)号：US20170056416A1
公开(公告)日：2017-03-02
申请号：US15352035
申请日：2016-11-15
IPC分类号： A61K31/568 , A61K31/4375 , A61K45/06
CPC分类号： A61K31/568 , A61K31/198 , A61K31/216 , A61K31/437 , A61K31/4375 , A61K31/7016 , A61K45/06 , A61K2300/00
摘要： The present invention provides the steroidal compound 3□-ethynyl-3□-hydroxyandrostan-17-one oxime, or a pharmaceutically acceptable salt thereof, for use in treatment of hepatic encephalopathy.
摘要翻译： 本发明提供了用于治疗肝性脑病的甾族化合物3'-乙炔基-3□ - 羟基和雄甾烷-17-酮肟或其药学上可接受的盐。
-
公开(公告)号：US10351589B2
公开(公告)日：2019-07-16
申请号：US15542800
申请日：2016-01-11
摘要： The invention relates to 3α-ethynyl, 3β-hydroxy, 5α-pregnan-20-oxime, represented by the following structural formula: or a pharmaceutically acceptable salt thereof, which compounds and/or salts are useful as modulators of the mammal brain excitability via the gamma-aminobutyric acid receptor-chloride ionophore (GABAA-R) complex and in the treatment of disorders such as hepatic encephalopathy, Down's syndrome and Alzheimer's disease.
-
公开(公告)号：US10342804B2
公开(公告)日：2019-07-09
申请号：US15716838
申请日：2017-09-27
IPC分类号： A61K45/06 , A61K31/198 , A61K31/216 , A61K31/437 , A61K31/568 , A61K31/4375 , A61K31/7016
摘要： The present invention provides the steroidal compound 3α-ethynyl-3β-hydroxyandrostan-17-one oxime, or a pharmaceutically acceptable salt thereof, for use in treatment of hepatic encephalopathy.
-
5.发明授权公开(公告)号：US09200028B2
公开(公告)日：2015-12-01
申请号：US13848782
申请日：2013-03-22
CPC分类号： C07J7/009 , C07J1/00 , C07J1/0011 , C07J5/0015 , C07J7/00 , C07J7/002 , C07J7/0065 , C07J7/007 , C07J41/00 , C07J41/0016 , C07J41/005
摘要： Steroid compounds having increased resistance against metabolism and increased water solubility are disclosed, together with methods for their production. These substances are suitable for the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and for use in methods of prevention, alleviation or treatment of such disorders.
摘要翻译： 公开了具有增加的耐代谢性和增加的水溶性的类固醇化合物及其生产方法。 这些物质适用于制备用于治疗类固醇相关或类固醇诱导的中枢神经系统疾病的药物，并且用于预防，减轻或治疗这些疾病的方法。
-
公开(公告)号：US10278977B2
公开(公告)日：2019-05-07
申请号：US15613539
申请日：2017-06-05
IPC分类号： A61K31/568 , A61K31/04 , A61K31/015
摘要： There is provided a method of treatment of hypersomnolence comprising administering the steroidal compound 3α-ethynyl-3β-hydroxy-5α-androstan-17-one oxime, or a pharmaceutically acceptable salt thereof, to a subject in need of such treatment.
-
公开(公告)号：US20180015103A1
公开(公告)日：2018-01-18
申请号：US15716838
申请日：2017-09-27
IPC分类号： A61K31/568 , A61K31/7016 , A61K31/4375 , A61K31/437 , A61K31/216 , A61K45/06 , A61K31/198
CPC分类号： A61K31/568 , A61K31/198 , A61K31/216 , A61K31/437 , A61K31/4375 , A61K31/7016 , A61K45/06 , A61K2300/00
摘要： The present invention provides the steroidal compound 3α-ethynyl-3β-hydroxyandrostan-17-one oxime, or a pharmaceutically acceptable salt thereof, for use in treatment of hepatic encephalopathy.
-
公开(公告)号：US20170348323A1
公开(公告)日：2017-12-07
申请号：US15613539
申请日：2017-06-05
IPC分类号： A61K31/568 , A61K31/015 , A61K31/04 , C07C205/05
CPC分类号： A61K31/568 , A61K31/015 , A61K31/04
摘要： There is provided a method of treatment of hypersomnolence comprising administering the steroidal compound 3α-ethynyl-3β-hydroxy-5α-androstan-17-one oxime, or a pharmaceutically acceptable salt thereof, to a subject in need of such treatment.
-
公开(公告)号：US09801894B2
公开(公告)日：2017-10-31
申请号：US15352035
申请日：2016-11-15
IPC分类号： A61K31/568 , A61K31/4375 , A61K45/06 , A61K31/198 , A61K31/216 , A61K31/437 , A61K31/7016
CPC分类号： A61K31/568 , A61K31/198 , A61K31/216 , A61K31/437 , A61K31/4375 , A61K31/7016 , A61K45/06 , A61K2300/00
摘要： The present invention provides the steroidal compound 3□-ethynyl-3□-hydroxyandrostan-17-one oxime, or a pharmaceutically acceptable salt thereof, for use in treatment of hepatic encephalopathy.
-
10.发明申请公开(公告)号：US20160272670A1
公开(公告)日：2016-09-22
申请号：US14945575
申请日：2015-11-19
CPC分类号： C07J7/009 , C07J1/00 , C07J1/0011 , C07J5/0015 , C07J7/00 , C07J7/002 , C07J7/0065 , C07J7/007 , C07J41/00 , C07J41/0016 , C07J41/005
摘要： Steroid compounds having increased resistance against metabolism and increased water solubility are disclosed, together with methods for their production. These substances are suitable for the manufacture of pharmaceuticals for the treatment of steroid related or steroid induced CNS disorders and for use in methods of prevention, alleviation or treatment of such disorders.
-
-
-
-
-
-
-
-
-
搜索结果
10 条记录 (耗时 0.017 秒)
