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1.发明申请公开(公告)号：US20150217045A1
公开(公告)日：2015-08-06
申请号：US14423565
申请日：2013-08-29
IPC分类号： A61M5/145
CPC分类号： A61M5/1454 , A61M5/1452 , A61M5/14546 , A61M5/14566 , A61M5/16804 , A61M2005/14208 , A61M2202/0007 , A61M2205/3334
摘要： A variable rate controlled delivery drive mechanism includes a drive mechanism housing, at least partially within which initially resides a biasing member positioned in an initially energized state within an inner cavity of a piston. The drive mechanism may include a gear drive having one or more screws and one or more corresponding nuts. The piston contacts a plunger seal and is configured to axially translate the plunger seal, by force asserted upon it from the biasing member, from a first position to a second position within a drug container for drug delivery. The biasing member is metered from free expansion from its energized state by the gear drive and a gear assembly mechanism having a motor. A drug delivery pump utilizes such variable rate controlled delivery mechanisms. A status reader configured to recognize one or more corresponding status triggers is utilized to provide feedback to a user.
摘要翻译： 可变速率控制传送驱动机构包括驱动机构壳体，驱动机构壳体至少部分地在其内初始位于在活塞的内腔内处于初始激励状态的偏置构件。 驱动机构可以包括具有一个或多个螺钉和一个或多个对应螺母的齿轮传动装置。 活塞接触柱塞密封件，并且构造成通过其从偏置构件被强制的力从柱塞密封件的第一位置轴向平移到用于药物递送的药物容器内的第二位置。 偏置构件通过齿轮传动从其通电状态的自由膨胀和具有电动机的齿轮组装机构计量。 药物输送泵利用这种可变速率控制递送机制。 用于识别一个或多个相应的状态触发器的状态读取器被用于向用户提供反馈。
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公开(公告)号：US20170281859A1
公开(公告)日：2017-10-05
申请号：US15625563
申请日：2017-06-16
发明人： Ryan M. Agard , Ian B. Hanson , Nicholas J. Ciccarelli , Sean M. O'Connor , Kevin Bokelman , Paul F. Bente, IV , John C. Love , Christopher Edward Hatch
CPC分类号： A61M5/14216 , A61M5/14248 , A61M5/1454 , A61M5/14566 , A61M5/172 , A61M2005/14252 , A61M2005/2474 , A61M2205/3317 , A61M2205/3379 , A61M2205/50 , A61M2205/58 , A61M2205/82
摘要： A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion.
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公开(公告)号：US09707335B2
公开(公告)日：2017-07-18
申请号：US14230784
申请日：2014-03-31
发明人： Ryan M. Agard , Ian B. Hanson , Nicholas J. Ciccarelli , Sean M. O'Connor , Kevin Bokelman , Paul F. Bente, IV , John C. Love , Christopher Edward Hatch
CPC分类号： A61M5/14216 , A61M5/14248 , A61M5/1454 , A61M5/14566 , A61M5/172 , A61M2005/14252 , A61M2005/2474 , A61M2205/3317 , A61M2205/3379 , A61M2205/50 , A61M2205/58 , A61M2205/82
摘要： A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing, the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion.
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公开(公告)号：US20140296787A1
公开(公告)日：2014-10-02
申请号：US14230784
申请日：2014-03-31
发明人： Ryan M. Agard , Ian B. Hanson , Nicholas J. Ciccarelli , Sean M. O'Connor , Kevin Bokelman , Paul F. Bente, IV , John C. Love , Christopher Edward Hatch
IPC分类号： A61M5/142
CPC分类号： A61M5/14216 , A61M5/14248 , A61M5/1454 , A61M5/14566 , A61M5/172 , A61M2005/14252 , A61M2005/2474 , A61M2205/3317 , A61M2205/3379 , A61M2205/50 , A61M2205/58 , A61M2205/82
摘要： A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing, the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion.
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公开(公告)号：US20180008769A1
公开(公告)日：2018-01-11
申请号：US15651807
申请日：2017-07-17
发明人： Sean M. O'Connor , Ian B. Hanson , Paul F. Bente, IV , Rajan Ramaswamy , Daniel S. Codd , Scott W. Beaver , Kevin L. Bokelman , John C. Love
CPC分类号： A61M5/14248 , A61M5/1452 , A61M5/162 , A61M5/16813 , A61M5/16877 , A61M2005/1581
摘要： A user-initiated fluid pathway connection includes: a connection hub, a piercing member, a sterile sleeve, and a drug container having a cap, a pierceable seal, a barrel, and a plunger seal, wherein the piercing member is initially retained within the sterile sleeve between the connection hub and the pierceable seal of the drug container. The connection hub may include an internal aperture within the connection hub which functions as a flow restrictor and wherein a piercing member is connected to one end of the internal aperture and a fluid conduit is connected to another end of the internal aperture. A drug delivery pump with integrated sterility maintenance features includes a housing, upon which an activation mechanism, an insertion mechanism, a fluid pathway connection as described above, a power and control system, and a drive mechanism connected to a drug container are mounted. Methods of assembly and operation are also provided.
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6.发明申请公开(公告)号：US20150141920A1
公开(公告)日：2015-05-21
申请号：US14605287
申请日：2015-01-26
CPC分类号： A61M5/172 , A61M5/1452 , A61M5/14566 , A61M2005/14506 , A61M2205/58
摘要： A drive mechanism having integrated status indication includes a drive housing, a status switch interconnect, a drive biasing member, a piston, and a drug container having a cap, a pierceable seal, a barrel, and a plunger seal, wherein the drive biasing member is configured to bear upon an interface surface of the piston. Drive mechanism may include an incremental status stem having a stem interconnect, wherein the stem resides within the drive housing and the piston, and wherein the stem has an interconnect which engages one or more contacts on the piston to provide incremental feedback. A drug delivery pump with integrated status indication includes a housing and an assembly platform, upon which an activation mechanism, an insertion mechanism, a fluid pathway connection, a power and control system, and the drive mechanism having a drug container may be mounted.
摘要翻译： 具有集成状态指示的驱动机构包括驱动器壳体，状态开关互连件，驱动偏压构件，活塞以及具有盖帽，可刺破密封件，筒体和柱塞密封件的药物容器，其中驱动偏置构件 构造成承载在活塞的界面表面上。 驱动机构可以包括具有杆互连的增量状态杆，其中杆位于驱动壳体和活塞内，并且其中杆具有与活塞上的一个或多个触点接合以提供增量反馈的互连。 具有集成状态指示的药物输送泵包括壳体和组装平台，可以安装激活机构，插入机构，流体通路连接，动力和控制系统以及具有药物容器的驱动机构。
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7.发明申请公开(公告)号：US20140200510A1
公开(公告)日：2014-07-17
申请号：US14163690
申请日：2014-01-24
发明人： Ryan M. Agard , Ian B. Hanson , Nicholas J. Ciccarelli , Sean M. O'Connor , Kevin Bokelman , Paul F. Bente, IV
CPC分类号： A61M5/14566 , A61M5/172 , A61M5/3157 , A61M2005/14252 , A61M2205/33 , A61M2205/50 , A61M2205/58 , A61M2205/82
摘要： A drive mechanism includes a housing, a piston adapted to impart movement to a plunger seal within a drug container, a plurality of biasing members disposed in parallel, and a retainer. The biasing members are disposed to release energy to cause movement of the piston from a retracted first position to the extended second position, the piston bearing against the plunger seal to dispense medicine. The retainer is disposed to maintain the biasing members in the energized position and to release the biasing members to permit the piston to dispense the medicine. The drive mechanism may also include an end-of-dose indicator to identify at least one of when the sleeve assembly is disposed subjacent a window in the housing, the relative motion of the sleeve assembly with reference to the window or another reference component, the stoppage of such motion, and the rated or change of rate of motion.
摘要翻译： 驱动机构包括壳体，活塞，适于使药物容器内的柱塞密封件移动，平行设置的多个偏置构件和保持器。 偏置构件设置成释放能量以使活塞从缩回的第一位置移动到延伸的第二位置，活塞抵靠柱塞密封件分配药物。 保持器被设置成将偏置构件保持在通电位置并且释放偏压构件以允许活塞分配药物。 驱动机构还可以包括剂量末端指示器，用于识别当套筒组件布置在壳体内的窗口下方时的至少一个，套筒组件相对于窗口或另一个参考部件的相对运动， 停止此类动作，以及运动速度的额定值或变化。
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公开(公告)号：US20150359965A1
公开(公告)日：2015-12-17
申请号：US14761853
申请日：2014-01-24
CPC分类号： A61M5/16813 , A61M5/141 , A61M5/14248 , A61M5/1452 , A61M5/1454 , A61M5/16822 , A61M2205/13
摘要： A replaceable fluid restriction mechanism includes: an aperture residing adjacent to a fluid pathway connection and configured to permit flow of a drug fluid through the aperture when the fluid pathway connection is open; an entry point of a fluid channel configured such that the flow of drug fluid can travel through aperture to the entry point and through the fluid channel to an exit point; and an outlet aperture of a port through which the flow of drug fluid may travel after exiting the exit point, wherein a fluid conduit is connected to the fluid restriction mechanism at the outlet aperture. A configurable fluid restriction mechanism includes a plurality of fluid channels, selectable to align with the entry point and an exit point of the fluid restriction mechanism.
摘要翻译： 可替换的流体限制机构包括：邻近流体通路连接的孔，并且构造成当流体通路连接打开时允许药物流体流过孔; 流体通道的入口点被配置为使得药物流体的流动可以通过孔口行进到入口点并且通过流体通道移动到出口点; 以及药物流体在离开出口点之后可以通过其移动的端口的出口孔，其中流体导管在出口孔处连接到流体限制机构。 可配置流体限制机构包括多个流体通道，其可选择地与流体限制机构的入口点和出口点对准。
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公开(公告)号：USD745142S1
公开(公告)日：2015-12-08
申请号：US29453258
申请日：2013-04-26
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10.发明申请公开(公告)号：US20150190588A1
公开(公告)日：2015-07-09
申请号：US14413120
申请日：2013-07-11
摘要： An insertion mechanism having a vented fluid pathway includes an insertion biasing member 210, a hub 212, a needle 214, a retraction biasing member 216, and a manifold 240 having a septum 230 and a cannula 234, wherein the annular space between the septum 230 and the cannula 234 defines a manifold header 242. The manifold and fluid conduit are ventable through the membrane prior to or just after needle 214 and cannula 234 are inserted into the user. Such insertion is caused by the insertion biasing member(s) 210, after which only the needle 214 or another occlusion element is retracted. Such retraction may open a fluid pathway from the manifold header 242 to the body through the cannula 234 and/or needle 214. A drug delivery pump 10 includes such an insertion mechanism 200 having a vented fluid pathway. The drug delivery pump 10 may contain the insertion mechanism 200 having a vented fluid pathway in either an internally i or an externally tethered configuration.
摘要翻译： 具有排出的流体通道的插入机构包括插入偏置构件210，毂212，针214，缩回偏压构件216和具有隔膜230和套管234的歧管240，其中隔膜230 并且套管234限定歧管集管242.在针214和插管234插入使用者之前或之后，歧管和流体导管可通过膜通气。 这种插入是由插入偏置构件210引起的，之后只有针214或另一个闭塞元件缩回。 这种缩回可以打开通过套管234和/或针214从歧管集管242到身体的流体路径。药物输送泵10包括具有排出的流体通路的这种插入机构200。 药物输送泵10可以包含插入机构200，该插入机构200具有在内部或外部连接构型中的排放的流体通路。
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