公开(公告)号：US20140371401A1

公开(公告)日：2014-12-18

申请号：US13919403

申请日：2013-06-17

申请人： Universidad de Talca ,  Fundación Fraunhofer Chile Research

发明人： Leonardo S. SANTOS ,  John AMALRAJ ,  Esteban F. DURAN LARA ,  Fabiane M. NACHTIGALL

IPC分类号： A61K47/48

CPC分类号： A61K47/48207 ,  A61K47/595 ,  C08L79/02 ,  C08L2203/02

摘要： The present invention is directed to a polymeric compound with a size in a nanometric scale, useful as a biocompatible carrier for the transport and delivery of active agents into a fish, insect, animal, reptile, bird, human, or plant, wherein said polymeric compound comprises PAMAM (polyamidoamine) dendrimers, a spacer molecule, and cafestol, wherein the polymeric compound of the invention comprises a structure of the kind (cafestol-PAMAM derivative)2-spacer molecule. Use of the compound as a biocompatible carrier for transport and delivery of antithrombotic active agents is disclosed. Procedures for obtaining a polymeric compound comprising the activation of cafestol, activation of polyethylene glycol, and formation of cafestol-PAMAM-PEG-PAMAM-cafestol are also disclosed.

摘要翻译： 本发明涉及一种尺寸为纳米级的聚合化合物，其可用作生物相容载体，用于将活性剂转运和递送至鱼，昆虫，动物，爬行动物，鸟，人或植物中，其中所述聚合物 化合物包括PAMAM（聚酰胺胺）树枝状大分子，间隔分子和咖啡豆，其中本发明的高分子化合物包含这种类型的结构（cafestol-PAMAM衍生物）2-间隔物分子。 公开了该化合物作为生物相容载体用于运输和递送抗血栓活性剂的用途。 还公开了用于获得包含活性咖啡醇，聚乙二醇的活化以及咖啡酚-PAMAM-PEG-PAMAM-cafestol的形成的聚合物的方法。