公开(公告)号：US11166987B2

公开(公告)日：2021-11-09

申请号：US15773524

申请日：2016-11-17

Applicant: Universität Basel

Inventor： Simon Ittig ,  Marlise Amstutz ,  Christoph Kasper ,  Guy R. Cornelis

IPC: A61K39/02 ,  A61P35/00 ,  A61K39/00 ,  A61K39/112 ,  A61K39/104 ,  C12N15/74 ,  A61K35/74

Abstract: The present invention relates to recombinant virulence attenuated Gram-negative bacterial strains for use in a method of treating a malignant solid tumor in a subject.

公开(公告)号：US20190015497A1

公开(公告)日：2019-01-17

申请号：US15773524

申请日：2016-11-17

Applicant: Universität Basel

Inventor： Simon Ittig ,  Marlise Amstutz ,  Christoph Kasper ,  Guy R. Cornelis

IPC: A61K39/02 ,  A61P35/00 ,  A61K39/00 ,  C12N15/74 ,  A61K39/104 ,  A61K39/112

Abstract: The present invention relates to recombinant virulence attenuated Gram-negative bacterial strains for use in a method of treating a malignant solid tumor in a subject.