公开(公告)号：US20240241195A1

公开(公告)日：2024-07-18

申请号：US18582293

申请日：2024-02-20

Applicant: NVISION IMAGING TECHNOLOGIES GMBH ,  UNIVERSITÄT ULM

Inventor： Ilai SCHWARTZ ,  Michael KEIM ,  Martin PLENIO ,  Benedikt TRATZMILLER

IPC: G01R33/28 ,  A61K49/10 ,  C07C67/14 ,  C07C67/293 ,  C07C69/716 ,  C07F7/08 ,  G01R33/46 ,  G01R33/44

CPC classification number: G01R33/282 ,  A61K49/10 ,  C07C67/14 ,  C07C67/293 ,  C07C69/716 ,  C07F7/081 ,  C07F7/083 ,  G01R33/4608 ,  C07B2200/05 ,  G01R33/445

Abstract: A method for preparing an NMR material, comprising generating parahydrogen in gas or liquid form at a first location; transporting the parahydrogen away from the first location; mixing a precursor compound including a metabolite component with a catalyst for hydrogenation; hydrogenating the precursor compound using the parahydrogen; transferring polarization in the precursor compound to a nuclear spin of the metabolite component; cleaving a side arm of the precursor compound in a chemical reaction, with the metabolite molecule being one of the products of the reaction; separating the metabolite molecule from the catalyst for hydrogenation and other products of the reaction; and generating metabolite molecules for use in an MRI scanner by extracting a sample of the metabolite molecule having at least 5% polarization.

公开(公告)号：US20180149717A1

公开(公告)日：2018-05-31

申请号：US15576018

申请日：2015-05-22

Applicant: Universität Ulm

Inventor： Fedor JELEZKO ,  Martin PLENIO ,  Ilai SCHWARTZ ,  Qiong CHEN ,  Alex RETZKER

IPC: G01R33/28 ,  G01R33/62 ,  G01R33/56 ,  G01R33/26

CPC classification number: G01R33/282 ,  G01N24/12 ,  G01R33/26 ,  G01R33/5601 ,  G01R33/62

Abstract: A method of hyperpolarisation of nuclear spins in one or more particle(s) moving relatively to a polarisation structure, wherein a polarisation of electron spins in the polarisation structure is transferred to the nuclear spins in the particle(s), wherein for one or more of the moving particle(s) within 20 nm from a surface of the polarisation structure, the correlation time of the interaction with the nearest polarisation structure electron spin due to the molecular motion is larger than the inverse of the nuclear Larmor frequency; the electron spins in the polarisation structure are polarised above thermal equilibrium; and the polarisation transfer is performed resonantly.