公开(公告)号：US20170096453A1

公开(公告)日：2017-04-06

申请号：US15379820

申请日：2016-12-15

申请人： UNIVERSITAET ZUERICH ,  POLYPHOR LTD.

发明人： Daniel OBRECHT ,  Frank GOMBERT ,  Steven J. DEMARCO ,  Christian LUDIN ,  Jan Wim VRIJBLOED ,  Kerstin MOEHLE ,  John-Anthony ROBINSON ,  Reshmi MUKHERJEE ,  Heiko HENZE ,  Barbara ROMAGNOLI

IPC分类号： C07K7/56

CPC分类号： C07K7/56 ,  A61K38/00 ,  A61K38/12 ,  C07K7/64

摘要： The template-fixed β-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity

公开(公告)号：US20170107259A1

公开(公告)日：2017-04-20

申请号：US15392586

申请日：2016-12-28

申请人： POLYPHOR LTD. ,  UNIVERSITAET ZUERICH

发明人： Steven J. DEMARCO ,  Wim VRIJBLOED ,  Ricardo DIAS ,  John Anthony ROBINSON ,  Nityakalyani SRINIVAS ,  Frank GOMBERT ,  Daniel OBRECHT

IPC分类号： C07K7/64

摘要： Template-fixed β-hairpin peptidomimetics of the general formula wherein Z is a template-fixed chain of 12 α-amino acid residues which, depending on their positions in the chain (counted starting from the N-terminal amino acid) are Gly, or Pro, or of certain types which, as the remaining symbols in the above formula, are defined in the description and the claims, and salts thereof, have the property to selectively inhibit the growth of or to kill microorganisms such as Pseudomonas aeruginosa. They can be used as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials, or as medicaments to treat or prevent infections.These β-hairpin peptidomimetics can be manufactured by processes which are based on a mixed solid and solution phase synthetic strategy.

公开(公告)号：US20190100558A1

公开(公告)日：2019-04-04

申请号：US16190459

申请日：2018-11-14

申请人： UNIVERSITAET ZUERICH ,  POLYPHOR LTD.

发明人： Daniel OBRECHT ,  Frank GOMBERT ,  Steven J. DEMARCO ,  Christian LUDIN ,  Jan Wim VBIJBLOED ,  Kerstin MOEHLE ,  John-Anthony ROBINSON ,  Reshmi MUKHERJEE ,  Heiko HENZE ,  Barbara ROMAGNOLI

IPC分类号： C07K7/56 ,  A61K38/12 ,  C07K7/64 ,  A61K38/00

摘要： The template-fixed β-hairpin peptidomimetics Cyclo(-Tyr-His-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gysll, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity

公开(公告)号：US20150080317A1

公开(公告)日：2015-03-19

申请号：US14555796

申请日：2014-11-28

申请人： Universitaet Zuerich ,  POLYPHOR LTD.

发明人： Daniel OBRECHT ,  Frank Gombert ,  Steven J. Demarco ,  Christian Ludin ,  Jan Wim Vrijbloed ,  Kerstin Moehle ,  John-Anthony Robinson ,  Reshmi Mukherjee ,  Heiko Henze ,  Barbara Romagnoli

IPC分类号： C07K7/64

CPC分类号： C07K7/56 ,  A61K38/00 ,  A61K38/12 ,  C07K7/64

摘要： The template-fixed B-hairpin peptidomimetics Cyclo(-Tyr-His-X-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro), disulfide bond between Cys4 and Gys11, and pharmaceutically acceptable salts thereof, with X being Ala or Tyr, have CXCR4 antagonizing properties and can be used for where cancer is mediated or resulting from CXCR4 receptor activity

摘要翻译： 模板固定的B发夹肽模拟物Cyclo（-Tyr-His-X-Cys-Ser-Ala-DPro-Dab-Arg-Tyr-Cys-Tyr-Gln-Lys-D-Pro-Pro），Cys4 和Gys11及其药学上可接受的盐，其中X为Ala或Tyr，具有CXCR4拮抗特性，可用于癌症介导或由CXCR4受体活性产生