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公开(公告)号：US10987413B2
公开(公告)日：2021-04-27
申请号：US15826879
申请日：2017-11-30
发明人： Dirk Schadendorf , Annette Paschen , Silke Lübcke , Martina Fatho , Daniela Eberts , Hakim Echchannaoui , Volker Lennerz , Catherine Woelfel , Thomas Woelfel
IPC分类号： A61K39/00 , C07K14/725 , C07K14/715 , C12N9/90 , G01N33/569 , A61K35/17 , G01N33/50 , A61K38/00
摘要： The present invention relates to novel tumor-associated antigens, which elicit independently from a presentation via MHC a CD8-positive T-cell response. GM-CSF-Receptor alpha chain (CSF2RA) and Tyrosinase-related protein 2 (TRP-2) were found to be targets of CD8-positive T-cell clones which could detect the proteins on the surface of HLA I negative melanoma cells. Thus, the invention provides proteins, protein fragments and polypeptides of the novel antigens for use in medicine, for example for the treatment, diagnosis and prevention of a tumor disease. Furthermore provided are nucleic acids expressing the antigens of the invention, binding agents specific for the antigens of the invention, such as T-cell receptor chains and isolated T cells which are reactive against the antigens of the invention or which express the T-cell receptors of the invention. The invention further pertains to pharmaceutical compositions, especially vaccine compositions, comprising the antigens, nucleic acids, binding agents or T cells in accordance with the invention, and methods for the generation of T cells, which are specifically reactive to the antigens of the invention in an MHC-independent manner.
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公开(公告)号：US09861688B2
公开(公告)日：2018-01-09
申请号：US14648703
申请日：2013-12-16
发明人： Dirk Schadendorf , Annette Paschen , Silke Luebcke , Martina Fatho , Daniela Eberts , Hakim Echchannaoui , Volker Lennerz , Catherine Woelfel , Thomas Woelfel
IPC分类号： A61K6/00 , A61K35/00 , A61K35/12 , A61K35/14 , A61K35/17 , A61K38/00 , A61K39/00 , C07K14/725 , C07K14/715 , C12N9/90 , G01N33/569 , G01N33/50
CPC分类号： A61K39/0011 , A61K35/17 , A61K38/00 , A61K2039/572 , A61K2039/585 , C07K14/7051 , C07K14/7153 , C12N9/90 , C12Y503/03012 , G01N33/5047 , G01N33/56972
摘要： The present invention relates to novel tumor-associated antigens, which elicit independently from a presentation via MHC a CD8-positive T-cell response. GM-CSF-Receptor alpha chain (CSF2RA) and Tyrosinase-related protein 2 (TRP-2) were found to be targets of CD8-positive T-cell clones which could detect the proteins on the surface of HLA I negative melanoma cells. Thus, the invention provides proteins, protein fragments and polypeptides of the novel antigens for use in medicine, for example for the treatment, diagnosis and prevention of a tumor disease. Furthermore provided are nucleic acids expressing the antigens of the invention, binding agents specific for the antigens of the invention, such as T-cell receptor chains and isolated T cells which are reactive against the antigens of the invention or which express the T-cell receptors of the invention. The invention further pertains to pharmaceutical compositions, especially vaccine compositions, comprising the antigens, nucleic acids, binding agents or T cells in accordance with the invention, and methods for the generation of T cells, which are specifically reactive to the antigens of the invention in an MHC-independent manner.
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