公开(公告)号：US20170016038A1

公开(公告)日：2017-01-19

申请号：US15224047

申请日：2016-07-29

申请人： Universiteit Gent

发明人： Jo Maertens ,  Joeri Beauprez ,  Marjan De Mey

IPC分类号： C12P19/14 ,  C12N15/52 ,  C12N9/90 ,  C12N9/26 ,  C12N9/10 ,  C12P19/18

摘要： The present invention relates to genetically engineered organisms, especially microorganisms such as bacteria and yeasts, for the production of added value bio-products such as specialty saccharide, activated saccharide, nucleoside, glycoside, glycolipid or glycoprotein. More specifically, the present invention relates to host cells that are metabolically engineered so that they can produce said valuable specialty products in large quantities and at a high rate by bypassing classical technical problems that occur in biocatalytical or fermentative production processes.

摘要翻译： 本发明涉及基因工程生物，特别是诸如细菌和酵母的微生物，用于生产附加价值的生物产品如特种糖，活性糖，核苷，糖苷，糖脂或糖蛋白。 更具体地，本发明涉及代谢工程化的宿主细胞，使得它们可以通过绕过在生物催化或发酵生产过程中发生的经典技术问题而以大量和高速率生产所述有价值的特种产品。

公开(公告)号：US12123041B2

公开(公告)日：2024-10-22

申请号：US17276793

申请日：2019-09-20

申请人： Universiteit Gent

发明人： Jo Maertens ,  David Bauwens ,  Wouter Van Bellegem ,  Pieter Coussement ,  Dries Duchi ,  Marjan De Mey

IPC分类号： C12P19/28 ,  C12N9/10 ,  C12P19/26 ,  C12P19/30 ,  C12P19/32 ,  C12P19/44

CPC分类号： C12P19/44 ,  C12P19/26 ,  C12Y205/01007

摘要： A method or producing amino sugar (containing) products using metabolically engineered microorganisms is disclosed, wherein the conversion of UDP-N-acetylglucosamine to cell envelope precursors and molecules is reduced by altering the activity of enzymes involved in the synthesis of cell envelope precursors and molecules.

公开(公告)号：US20210355520A1

公开(公告)日：2021-11-18

申请号：US17276793

申请日：2019-09-20

申请人： Universiteit Gent

发明人： Jo Maertens ,  David Bauwens ,  Wouter Van Bellegem ,  Pieter Coussement ,  Dries Duchi ,  Marjan De Mey

IPC分类号： C12P19/44 ,  C12P19/26

摘要： A method or producing amino sugar (containing) products using metabolically engineered microorganisms is disclosed, wherein the conversion of UDP-N-acetylglucosamine to cell envelope precursors and molecules is reduced by altering the activity of enzymes involved in the synthesis of cell envelope precursors and molecules.