公开(公告)号：US20150376723A1

公开(公告)日：2015-12-31

申请号：US14753266

申请日：2015-06-29

Applicant: University Health Network

Inventor： Shaf Keshavjee ,  Marcelo Cypel ,  Shahid Husain ,  Mingyao Liu

IPC: C12Q1/70

CPC classification number: C12Q1/701 ,  C12Q1/6883 ,  C12Q2600/158

Abstract: Described are biomarkers and associated methods for identifying a subject having, or at risk of developing, severe illness from influenza. The level of one or more biomarkers in a test sample from the subject is determined and compared to a control level. Optionally, the subject has or is suspected of having H1N1 influenza. In some embodiments the biomarkers may include IL23R, IL10, TNFRSF13B, CX3CR1, CCR2, MAP2K3 and/or IRF1. In some embodiments, the biomarkers include a combination of IL2 and IL23R or IL10 and IL23R. Also described are methods which include determining the level of two or more biomarkers in a sample and multivariate methods are used for comparing the levels in the test sample to the level in a control sample.

Abstract translation: 描述了用于识别具有或有发展为流感的严重疾病的风险的受试者的生物标志物和相关方法。 确定来自受试者的测试样品中的一种或多种生物标志物的水平并与对照水平进行比较。 任选地，受试者患有或怀疑患有H1N1流感。 在一些实施方案中，生物标志物可以包括IL23R，IL10，TNFRSF13B，CX3CR1，CCR2，MAP2K3和/或IRF1。 在一些实施方案中，生物标志物包括IL2和IL23R或IL10和IL23R的组合。 还描述了包括确定样品中两种或更多种生物标志物的水平的方法，并且多变量方法用于将测试样品中的水平与对照样品中的水平进行比较。