公开(公告)号：US20230372475A1

公开(公告)日：2023-11-23

申请号：US18247962

申请日：2022-09-02

Applicant: UNIVERSITY OF CONNECTICUT ,  EASTERN VIRGINIA MEDICAL SCHOOL

Inventor： Vivek Agrahari ,  Gustavo Fabian Doncel ,  Thanh Duc Nguyen ,  Feng Lin ,  Khanh Tran ,  Onkar Nath Singh

IPC: A61K39/39 ,  A61K9/127 ,  A61K47/54 ,  A61K47/26 ,  A61K39/395 ,  A61K39/215 ,  A61K9/00

CPC classification number: A61K39/39 ,  A61K9/1272 ,  A61K47/543 ,  A61K47/26 ,  A61K39/39591 ,  A61K39/215 ,  A61K9/0021 ,  A61K2039/53

Abstract: Described herein are compositions and methods for stabilizing RNA and protein antigens for long-term storage and use in transdermal microneedle patches, methods for filling microneedles, and methods of use. A stabilized RNA vaccine composition comprises: a complex of RNA with one or more cationic polymers; and one or more cationic lipid entities. A method for stabilizing RNA comprises: forming a complex comprising the RNA with one or more cationic polymers; mixing the complex with one or more cationic lipid entities comprising liposomes or lipid nanoparticles to form a lipid mixture; and drying the lipid mixture under vacuum. The compositions and methods may be employed in the preparation of vaccine medicaments.

公开(公告)号：US20220355089A1

公开(公告)日：2022-11-10

申请号：US17871490

申请日：2022-07-22

Applicant: University of Connecticut

Inventor： Thanh D. Nguyen ,  Khanh Tran

IPC: A61M37/00 ,  A61B17/20 ,  B29C41/00 ,  B29C43/00 ,  B29C65/02 ,  B29C43/32 ,  B29C43/02 ,  B29C39/00 ,  B29C39/02

Abstract: A core-shell microneedle system and a method of manufacturing the microneedle system provides a pulsatile drug delivery system which is programmed to release drugs/vaccines at predictable times using biodegradable polymers and with controllable dosages. This microneedle system can be fully embedded into the skin and then release drugs/vaccines as sharp bursts in a timely manner, similar to multiple bolus injections.

公开(公告)号：US11426570B2

公开(公告)日：2022-08-30

申请号：US16293588

申请日：2019-03-05

Applicant: University of Connecticut

Inventor： Thanh D. Nguyen ,  Khanh Tran

IPC: A61M37/00 ,  A61B17/20 ,  B29C41/00 ,  B29C43/00 ,  B29C65/02 ,  B29C43/32 ,  B29C43/02 ,  B29C39/00 ,  B29C39/02

Abstract: A core-shell microneedle system and a method of manufacturing the microneedle system provides a pulsatile drug delivery system which is programmed to release drugs/vaccines at predictable times using biodegradable polymers and with controllable dosages. This microneedle system can be fully embedded into the skin and then release drugs/vaccines as sharp bursts in a timely manner, similar to multiple bolus injections.

公开(公告)号：US20190269895A1

公开(公告)日：2019-09-05

申请号：US16293588

申请日：2019-03-05

Applicant: University of Connecticut

Inventor： Thanh D. Nguyen ,  Khanh Tran

IPC: A61M37/00 ,  A61B17/20

Abstract: A core-shell microneedle system and a method of manufacturing the microneedle system provides a pulsatile drug delivery system which is programmed to release drugs/vaccines at predictable times using biodegradable polymers and with controllable dosages. This microneedle system can be fully embedded into the skin and then release drugs/vaccines as sharp bursts in a timely manner, similar to multiple bolus injections.