公开(公告)号：US20220117206A1

公开(公告)日：2022-04-21

申请号：US17504752

申请日：2021-10-19

申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED

发明人： Liya Pi ,  Daohong Zhou

IPC分类号： A01K67/027

摘要： Described are alcohol-induced liver cancer model mice, methods of generating the alcohol-induced liver cancer model mice, and methods of using the alcohol-induced liver cancer model mice. Methods of treating alcoholic liver disease, including hepatocellular carcinoma, are also described.

公开(公告)号：US20230339929A1

公开(公告)日：2023-10-26

申请号：US17790211

申请日：2021-01-15

申请人： University of Florida Research Foundation, Incorporated

发明人： Guangrong Zheng ,  Daohong Zhou ,  Xuan Zhang ,  Wanyi HU ,  Xingui Liu ,  Dongwen Lyu ,  Yaxia Yuan ,  Dinesh Thummuri

IPC分类号： C07D417/14 ,  A61K45/06 ,  A61P35/02 ,  A61K31/4725

CPC分类号： C07D417/14 ,  A61K45/06 ,  A61P35/02 ,  A61K31/4725

摘要： The invention is directed towards compounds (e.g., Formula (I) or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof), their mechanism of action, and methods of modulating proliferation activity, and methods of treating diseases and disorders using the compounds described herein (e.g., Formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof).

公开(公告)号：US20220169628A1

公开(公告)日：2022-06-02

申请号：US17429207

申请日：2020-02-07

申请人： University of Florida Research Foundation, Incorporated

发明人： Guangrong Zheng ,  Daohong Zhou ,  Pratik Pal ,  Xingui Liu ,  Dinesh Thummuri ,  Wanyi HU ,  Peiyi Zhang ,  Dongwen Lyu ,  Yaxia Yuan ,  Xuan Zhang

IPC分类号： C07D401/04 ,  C07D417/12 ,  A61P35/02 ,  C07D417/14 ,  A61K45/06

摘要： The invention is directed towards compounds (e.g., Formula (I)), their mechanism of action, and methods of modulating proliferation activity, and methods of treating diseases and disorders using the compounds described herein (e.g., Formula (I)).

公开(公告)号：US20230330237A1

公开(公告)日：2023-10-19

申请号：US18023696

申请日：2021-08-27

申请人： University of Florida Research Foundation, Incorporated

发明人： Weizhou Zhang ,  Guangrong Zheng ,  Daohong Zhou ,  Yufeng Xiao ,  Lei Wang

IPC分类号： A61K47/55 ,  A61P35/00 ,  A61K45/06

CPC分类号： A61K47/55 ,  A61P35/00 ,  A61K45/06

摘要： Modulators of Nuclear Receptor Subfamily 4 Group A Member 1 (NR4A1) are described as well as their use as therapeutic agents for disease, disorders, or symptoms thereof, including those where modulation of NR4A1 is implicated. Such disease and disorders include cancer.