公开(公告)号：US20240182471A1

公开(公告)日：2024-06-06

申请号：US18505603

申请日：2023-11-09

Applicant: University of Florida Research Foundation, Inc.

Inventor： Alexander James GRENNING ,  Ehsan FEREYDUNI

IPC: C07D471/08 ,  C07C255/31 ,  C07C255/34 ,  C07D317/72

CPC classification number: C07D471/08 ,  C07C255/31 ,  C07C255/34 ,  C07D317/72

Abstract: In one aspect, the disclosure relates to methods for preparation of intermediates useful for the preparation of aryl-cycloheptene scaffolds. In a further aspect, the disclosed methods pertain to the preparation of compounds comprising an aryl-cycloheptene structure. The disclosed methods utilize abundant starting materials and simple reaction sequences that can be used to modularly and scalably assemble common such cores. In various aspects, the present disclosure pertains to compounds prepared using the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20220106284A1

公开(公告)日：2022-04-07

申请号：US17435901

申请日：2020-03-04

Applicant: University of Florida Research Foundation, Inc.

Inventor： Alexander James GRENNING ,  Primali Vasundera NAVARATNE

IPC: C07D311/80 ,  C07B53/00

Abstract: In one aspect, the disclosure relates to substituted axially-chiral cannabinol analogs, methods of making same, pharmaceutical compositions comprising same, and methods of treating pain using same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.