公开(公告)号：US11505470B2

公开(公告)日：2022-11-22

申请号：US17051904

申请日：2019-05-03

Applicant: University of Florida Research Foundation, Inc.

Inventor： George Christou ,  Bradley Keith Russell-Webster

IPC: C01F17/00 ,  C01F17/235 ,  C07F9/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  B01J37/00

Abstract: Described herein are compositions and methods relating to molecular cerium-oxide nanoclusters. Described herein are methods of producing cerium-oxide nanoclusters. Described herein are cerium-oxide nanoclusters. Further described herein are cerium-oxide nanoclusters produced by methods as described herein. Methods as described herein can comprise providing a first cerium source, an organic acid, and a solvent; and mixing the cerium source and the organic acid in the presence of a solvent to create a reaction mixture at a temperature and a pressure for a period of time to create a composition of molecular cerium-oxide nanoclusters containing a plurality of molecular cerium-oxide nanoclusters.

公开(公告)号：US11207663B2

公开(公告)日：2021-12-28

申请号：US16467088

申请日：2017-12-06

Applicant: University of Florida Research Foundation, Inc.

Inventor： George Christou ,  Kylie J. Mitchell

IPC: C01F17/30 ,  C01F17/235 ,  B01J23/10

Abstract: Described herein are compositions and methods relating to molecular cerium-oxide nanoclusters. In an aspect, described herein are methods of synthesizing molecular cerium-oxide nanocluster compositions and compositions thereof. In an aspect, described herein are methods of scavenging reactive oxygen species utilizing molecular cerium-oxide nanoclusters as described herein. Also described herein are pharmaceutical compositions and methods of use. Pharmaceutical compositions as described herein can comprise a therapeutically effective amount of a compound (such as a composition comprising one or more molecular cerium-oxide nanoclusters), or a pharmaceutically acceptable salt of the compound, and a pharmaceutically acceptable carrier. Methods of treating oxidative stress are also described herein, comprising administering pharmaceutical compositions as described herein to a subject in need thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.