公开(公告)号：US20140377374A1

公开(公告)日：2014-12-25

申请号：US14376027

申请日：2013-02-08

Applicant: University of Florida Research Foundation, Inc.

Inventor： Sadasivan Vidyasagar ,  Paul Okunieff ,  Lurong Zhang

IPC: A61K33/20 ,  A61K33/00 ,  A61K31/405 ,  A61K31/198 ,  A61K31/205

CPC classification number: A61K33/00 ,  A61K9/0095 ,  A61K31/198 ,  A61K31/205 ,  A61K31/405 ,  A61K33/06 ,  A61K33/20 ,  A61K45/06 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/481 ,  A61K2300/00

Abstract: The present invention provides therapeutic compositions and methods for treating gastrointestinal diseases and conditions such as diarrhea, for providing rehydration, for correcting electrolyte and fluid imbalances, and/or for improving small intestine function. In one embodiment, the present invention provides a composition formulated for enteral administration, wherein the composition does not contain glucose. In a preferred embodiment, the composition is formulated for administration as an oral rehydration drink.

Abstract translation: 本发明提供用于治疗胃肠疾病和腹泻的治疗组合物和方法，用于提供补液，用于校正电解质和流体不平衡，和/或用于改善小肠功能。 在一个实施方案中，本发明提供配制用于肠内施用的组合物，其中所述组合物不含葡萄糖。 在优选的实施方案中，将组合物配制成作为口服补液饮料施用。

公开(公告)号：US10350185B2

公开(公告)日：2019-07-16

申请号：US14773960

申请日：2014-03-11

Applicant: University of Florida Research Foundation, Inc.

Inventor： Sadasivan Vidyasagar ,  Paul Okunieff

IPC: A61K33/14 ,  A61K9/00 ,  A61K31/198 ,  A61K31/405

Abstract: The subject invention provides therapeutic compositions and uses thereof for improving pulmonary function. In one embodiment, the therapeutic composition comprises one or more free amino acids selected from lysine, glycine, threonine, valine, tyrosine, aspartic acid, isoleucine, tryptophan, asparagine, and serine; and electrolytes. In one embodiment, the subject invention can be used to prevent or treat long-term lung complications induced by radiation.