公开(公告)号：US20190153470A1

公开(公告)日：2019-05-23

申请号：US15743459

申请日：2016-07-11

申请人： University of Guelph

发明人： Yanlong PEI ,  James ACKFORD ,  Juan Carlos CORREDOR ,  Peter J. KRELL ,  Eva NAGY

IPC分类号： C12N15/86

摘要： Described are recombinant viral vectors obtained from fowl adenovirus 9 (FAdV-9) and associated methods. The recombinant FAdV-9 vectors may include one or more deletions at the left end and/or right end of the FAdV-9 genome. Optionally, the vectors include one or more exogenous nucleotide sequences, such a sequences encoding for a polypeptide of interest. The recombinant FAdV-9 vectors may be used as a dual delivery vector. Also described is the use of the vectors for generating an immunogenic response in a subject and/or for the prevention of disease.