公开(公告)号：US11821660B2

公开(公告)日：2023-11-21

申请号：US17715651

申请日：2022-04-07

申请人： University of Guelph

发明人： Adam Zimmer ,  Timothy Mills ,  Matthew Drummond

IPC分类号： F25B21/04 ,  F25B49/00 ,  F25D11/00 ,  F25D29/00 ,  A61J1/16

CPC分类号： F25B21/04 ,  A61J1/165 ,  F25B49/00 ,  F25D11/003 ,  F25D29/003 ,  F25B2321/0211 ,  F25B2321/0251 ,  F25B2321/0252 ,  F25B2700/2104 ,  F25D2201/14 ,  F25D2700/12

摘要： At least one method and container are described for maintaining a target temperature within the container. The container generally includes a vacuum insulated body; a lid couplable to the vacuum insulated body; a heatsink, coupled to the lid, wherein a portion of the heatsink is positionable within the vacuum insulated body; and at least one thermoelectric cell coupled to the heatsink, wherein the at least one thermoelectric cell is operated to promote the transfer of heat between the inside of the container and the outside of the container to cool the inside of the container or to warm the inside of the container. The container may be arranged so that internal and external portions of the heatsink may be arranged in a decoupled position to reduce heat transfer therebetween.

公开(公告)号：US20220396809A1

公开(公告)日：2022-12-15

申请号：US17831894

申请日：2022-06-03

申请人： University of Guelph

发明人： Sarah Wootton ,  Leonardo Susta ,  Byram Bridle ,  Pierre Major ,  Lisa Santry ,  Yanlong Pei

IPC分类号： C12N15/86 ,  C07K14/005 ,  A61K39/17 ,  A61K39/215 ,  A61P35/00 ,  A61P31/14

摘要： An engineered Newcastle Disease Virus (NDV) vector is provided. In particular, the present disclosure provides methods of treating or preventing a disease such as cancer, or an infectious disease, or methods for eliciting an immune response, with the engineered NDV vector. The engineered NDV vector provided herein is useful as an immunogenic composition, an oncolytic agent, or a vaccine.

公开(公告)号：US20220220067A1

公开(公告)日：2022-07-14

申请号：US17614357

申请日：2020-05-28

申请人： University of Guelph

发明人： Amr Zaitoon ,  Loong-Tak Lim ,  Cynthia Scott-Dupree

IPC分类号： C07C251/74 ,  C07C243/28

摘要： The present disclosure relates to compounds of the formula (I) which are precursor compounds of esters, whereby upon hydrolysis of the precursor compound, an ester compound is released. This ester precursor approach can be useful for applications where controlled release of, for example, ethyl formate, is beneficial.

公开(公告)号：US10472440B2

公开(公告)日：2019-11-12

申请号：US15674015

申请日：2017-08-10

申请人： University of Guelph

发明人： Amar K. Mohanty ,  Manju Misra ,  Ehsan Behazin ,  Arturo Rodriguez-Uribe

IPC分类号： C08F210/06 ,  C08F210/14 ,  C09C1/48 ,  C08K5/00 ,  C08L23/10

摘要： Toughened polyolefins and methods used to produce toughened polyolefins in presence of a bio-filler. These materials can substitute traditional thermoplastic polyolefins known as TPOs or mineral filled TPOs. Exemplary compositions include a phase based on α-olefin elastomers and the use of biobased fillers. The bio-based filler used, can be a material rich in elemental carbon content. The use of additives is of regular usage for these compositions as they may be related to coupling agents, UV absorbers, light stabilizers, antioxidants, and so forth. These composition offer a remarkable lower density compared to traditional TPOs compositions altogether with bio-based value-performance addition.

公开(公告)号：US10414880B2

公开(公告)日：2019-09-17

申请号：US15126187

申请日：2015-03-13

申请人： University of Guelph

发明人： Amar Mohanty ,  Manjusri Misra ,  Atul Bali ,  Arturo Rodriguez-Uribe

IPC分类号： C08J3/22 ,  C08L27/06 ,  C08L23/12 ,  C08K3/04 ,  B09B3/00 ,  C08L101/00 ,  C08L23/06

摘要： Biocarbon is presented as an alternative to synthetic carbon black. Master batches having biocarbon for usage in raw plastics and/or the production of composites. Biocarbon is mainly derived from plant biomass, but other sources can be used. A method of producing the master batch: (a) pyrolyzing processed biomass in an oxygen-starved environment to produced biocarbon; (b) comminuting the biocarbon in a reduced oxygen atmosphere; (c) cooling the comminuted biocarbon; (d) mixing the cooled comminuted biocarbon with a carrier resin, thereby producing the master batch.

公开(公告)号：US20190153470A1

公开(公告)日：2019-05-23

申请号：US15743459

申请日：2016-07-11

申请人： University of Guelph

发明人： Yanlong PEI ,  James ACKFORD ,  Juan Carlos CORREDOR ,  Peter J. KRELL ,  Eva NAGY

IPC分类号： C12N15/86

摘要： Described are recombinant viral vectors obtained from fowl adenovirus 9 (FAdV-9) and associated methods. The recombinant FAdV-9 vectors may include one or more deletions at the left end and/or right end of the FAdV-9 genome. Optionally, the vectors include one or more exogenous nucleotide sequences, such a sequences encoding for a polypeptide of interest. The recombinant FAdV-9 vectors may be used as a dual delivery vector. Also described is the use of the vectors for generating an immunogenic response in a subject and/or for the prevention of disease.

公开(公告)号：US09879057B2

公开(公告)日：2018-01-30

申请号：US15024238

申请日：2014-09-24

申请人： University of Guelph

发明人： Lucy M. Mutharia ,  Antonio Facciuolo

IPC分类号： A61K39/04 ,  C07K14/35 ,  G01N33/569 ,  C07K16/12

CPC分类号： C07K14/35 ,  A61K39/04 ,  C07K16/1289 ,  C07K2317/33 ,  G01N33/5695 ,  G01N2333/35 ,  G01N2469/20

摘要： Described are methods and products useful for identifying subjects with Mycobacterium avium subspecies paratuberculosis (MAP). A number of protein antigens secreted into culture filtrate by MAP are identified and binding proteins selective for these antigens are demonstrated to be useful for detecting subjects with MAP infections including subjects with Johne's disease.

公开(公告)号：US20170284102A1

公开(公告)日：2017-10-05

申请号：US15508171

申请日：2015-09-08

申请人： University of Guelph

发明人： Greg Yuristy ,  Youbin Zheng

IPC分类号： E04D11/00 ,  D06N5/00 ,  A01G1/00

CPC分类号： A01G20/00 ,  A01G9/033 ,  D06N5/00 ,  E04D11/002 ,  Y02A30/254 ,  Y02B80/32

摘要： A green roofing substrate brick comprises a water-permeable fabric box having an open top, and a solidified and non-compressed substrate in the box. The substrate comprises a water storage and drainage medium, and a binder solidifying the water storage and drainage medium.

公开(公告)号：US09562156B2

公开(公告)日：2017-02-07

申请号：US14796508

申请日：2015-07-10

申请人： University of Guelph

发明人： Manjusri Misra ,  Ryan Vadori ,  Amar Kumar Mohanty

IPC分类号： C08L67/02 ,  C08L55/02 ,  C08L67/08

CPC分类号： C08L55/02 ,  C08L2201/08 ,  C08L2205/035 ,  C08L33/00 ,  C08L67/04

摘要： A high performance acrylonitrile butadiene styrene (ABS) polymer blend comprising ABS, polylactic acid (PLA), an acrylic copolymer based lubricant and a polymeric chain extender.

摘要翻译： 包含ABS，聚乳酸（PLA），丙烯酸共聚物基润滑剂和聚合物增链剂的高性能丙烯腈丁二烯苯乙烯（ABS）聚合物共混物。

公开(公告)号：US09447127B2

公开(公告)日：2016-09-20

申请号：US14030719

申请日：2013-09-18

申请人： University of Rochester ,  University of Guelph ,  The Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center

发明人： Robert H. Notter ,  Zhengdong Wang ,  Adrian L. Schwan ,  Zhongyi Wang ,  Jason A. Davy ,  Alan J Waring ,  Frans Walther ,  Larry M. Gordon

IPC分类号： A61K38/00 ,  C07F9/09 ,  A61K9/00 ,  C07F9/40 ,  C07K14/00 ,  C07K14/785

CPC分类号： C07F9/091 ,  A61K9/0082 ,  C07F9/4006 ,  C07F9/4075 ,  C07K14/001 ,  C07K14/785

摘要： The present invention relates to synthetic lung surfactant compositions that contain one or more of phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active proteins or peptides, more preferably a combination of at least two or all three of these materials. Novel phospholipase-resistant phospho-glycerol derivatives, phospholipase-resistant phospho-choline derivatives, and surface active peptides are also disclosed herein. Uses of the surfactant compositions of the present invention to treat endogenous surfactant dysfunctional or deficient lung tissue, to prepare synthetic peptides for use in the surfactant compositions, and to deliver therapeutic agents are also disclosed.