公开(公告)号：US20250017885A1

公开(公告)日：2025-01-16

申请号：US18770447

申请日：2024-07-11

Applicant: University of Kansas

Inventor： Duaa Jabari ,  Richard J. Barohn ,  Mazen M. Dimachkie ,  Heather Wilkins

IPC: A61K31/192 ,  C12Q1/6876 ,  G01N33/52

Abstract: A method for treating inclusion body myositis (IBM) in a subject can include: providing a subject that has IBM; administering phenylbutyrate (PBA) to the subject in a therapeutically effective amount to provide a treatment for the IBM; obtaining at least one biological sample from the subject after initiation of the treatment for the IBM; measuring a biological indicator in the at least one biological sample, wherein the biological indicator is mitochondrial membrane potential; and monitoring a change in the biological indicator as an indication of effectiveness of the treatment.