公开(公告)号：US20210317067A1

公开(公告)日：2021-10-14

申请号：US17280235

申请日：2019-09-30

Applicant: University of Kansas

Inventor： Russell Swerdlow ,  Laird Forrest ,  Jordan Hunt ,  Heather Wilkins ,  Eli Michaelis

IPC: C07C69/716 ,  A61P25/28

Abstract: Compounds, compositions, and methods related to bioenergetic metabolism are provided. The compounds and com positions are suited to promote bioenergetic processes including cellular respiration and glycolytic flux and may be used to treat mitochondrial disorders, neurodegenerative diseases (such as Alzheimer's disease (AD), Parkinson's disease, and/or amyotrophic lateral sclerosis), multiple sclerosis, and/or epilepsy.

公开(公告)号：US11952337B2

公开(公告)日：2024-04-09

申请号：US17745773

申请日：2022-05-16

Applicant: University of Kansas

Inventor： Russell Swerdlow ,  Laird Forrest ,  Jordan Hunt ,  Heather Wilkins ,  Eli Michaelis

IPC: C07C69/716 ,  A61P25/28

CPC classification number: C07C69/716 ,  A61P25/28

Abstract: Compounds, compositions, and methods related to bioenergetic metabolism are provided. The compounds and compositions are suited to promote bioenergetic processes including cellular respiration and glycolytic flux and may be used to treat mitochondrial disorders, neurodegenerative diseases (such as Alzheimer's disease (AD), Parkinson's disease, and/or amyotrophic lateral sclerosis), multiple sclerosis, and/or epilepsy.

公开(公告)号：US20250017885A1

公开(公告)日：2025-01-16

申请号：US18770447

申请日：2024-07-11

Applicant: University of Kansas

Inventor： Duaa Jabari ,  Richard J. Barohn ,  Mazen M. Dimachkie ,  Heather Wilkins

IPC: A61K31/192 ,  C12Q1/6876 ,  G01N33/52

Abstract: A method for treating inclusion body myositis (IBM) in a subject can include: providing a subject that has IBM; administering phenylbutyrate (PBA) to the subject in a therapeutically effective amount to provide a treatment for the IBM; obtaining at least one biological sample from the subject after initiation of the treatment for the IBM; measuring a biological indicator in the at least one biological sample, wherein the biological indicator is mitochondrial membrane potential; and monitoring a change in the biological indicator as an indication of effectiveness of the treatment.

公开(公告)号：US11332432B2

公开(公告)日：2022-05-17

申请号：US17280235

申请日：2019-09-30

Applicant: University of Kansas

Inventor： Russell Swerdlow ,  Laird Forrest ,  Jordan Hunt ,  Heather Wilkins ,  Eli Michaelis

IPC: C07C69/716 ,  A61P25/28

Abstract: Compounds, compositions, and methods related to bioenergetic metabolism are provided. The compounds and com positions are suited to promote bioenergetic processes including cellular respiration and glycolytic flux and may be used to treat mitochondrial disorders, neurodegenerative diseases (such as Alzheimer's disease (AD), Parkinson's disease, and/or amyotrophic lateral sclerosis), multiple sclerosis, and/or epilepsy.