公开(公告)号：US20190241612A1

公开(公告)日：2019-08-08

申请号：US16383016

申请日：2019-04-12

Applicant: University of Kansas

Inventor： Jane V. Aldrich ,  S P Sanjeewa Nilendra Senadheera

IPC: C07K5/12

CPC classification number: C07K5/126 ,  A61K38/00 ,  C07K5/12

Abstract: Cyclic tetrapeptide stereochemical isomers of CJ-15,208, pharmaceutical compositions from such cyclic tetrapeptides, and methods of using such pharmaceutical compositions. The cyclic tetrapeptide compounds and pharmaceutical compositions disclosed herein are potent analgesics active in several pain models with generally minimal tolerance and reduced likelihood to induce addiction relative to other known opiates.

公开(公告)号：US20170190738A1

公开(公告)日：2017-07-06

申请号：US15325177

申请日：2015-07-13

Applicant: University of Kansas

Inventor： Jane V. Aldrich ,  S P Sanjeewa Nilendra Senadheera

IPC: C07K5/12

CPC classification number: C07K5/126 ,  A61K38/00 ,  C07K5/12

Abstract: Cyclic tetrapeptide stereochemical isomers of CJ-15,208, pharmaceutical compositions from such cyclic tetrapeptides, and methods of using such pharmaceutical compositions. The cyclic tetrapeptide compounds and pharmaceutical compositions disclosed herein are potent analgesics active in several pain models with generally minimal tolerance and reduced likelihood to induce addiction relative to other known opiates.

公开(公告)号：US10259843B2

公开(公告)日：2019-04-16

申请号：US15325177

申请日：2015-07-13

Applicant: University of Kansas

Inventor： Jane V. Aldrich ,  S P Sanjeewa Nilendra Senadheera

IPC: C07K5/12 ,  A61K38/00

Abstract: Cyclic tetrapeptide stereochemical isomers of CJ-15,208, pharmaceutical compositions from such cyclic tetrapeptides, and methods of using such pharmaceutical compositions. The cyclic tetrapeptide compounds and pharmaceutical compositions disclosed herein are potent analgesics active in several pain models with generally minimal tolerance and reduced likelihood to induce addiction relative to other known opiates.

公开(公告)号：US10988506B2

公开(公告)日：2021-04-27

申请号：US16383016

申请日：2019-04-12

Applicant: University of Kansas

Inventor： Jane V. Aldrich ,  S P Sanjeewa Nilendra Senadheera

IPC: C07K5/12 ,  A61K38/00

Abstract: Cyclic tetrapeptide stereochemical isomers of CJ-15,208, pharmaceutical compositions from such cyclic tetrapeptides, and methods of using such pharmaceutical compositions. The cyclic tetrapeptide compounds and pharmaceutical compositions disclosed herein are potent analgesics active in several pain models with generally minimal tolerance and reduced likelihood to induce addiction relative to other known opiates.