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公开(公告)号：US20160075669A1
公开(公告)日：2016-03-17
申请号：US14851835
申请日：2015-09-11
IPC分类号： C07D277/56 , C07D513/04
CPC分类号： C07D277/56 , C07D513/04
摘要： A compound that can function as a Cyclophilin D can include a structure of Formula 1 or Formula 2 or Formula 3 or Formula 4 or Formula 5 or Formula 6 or Formula 7 or Formula 8, derivative thereof, prodrug thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof, as presented herein. The Cyclophilin D inhibitors can inhibit onset or treat neurodegenerative disease, such as Alzheimer's disease, or can be used for inhibiting progression or treating diabetes.
摘要翻译： 可用作环丙氯林D的化合物可以包括式1或式2或式3或式4或式5或式6或式7或式8的化合物的衍生物，其前药，其盐或其立体异构体 ，或在任何手性中心或其互变异构体，多晶型物，溶剂化物或其组合下具有任何手性，如本文所呈现的。 亲环蛋白D抑制剂可抑制发病或治疗诸如阿尔茨海默病的神经变性疾病，或可用于抑制进展或治疗糖尿病。
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2.发明授权公开(公告)号：US09738668B2
公开(公告)日：2017-08-22
申请号：US15163275
申请日：2016-05-24
申请人： University of Kansas
发明人： ShiDu Yan , Koteswara Rao Valasani
IPC分类号： C07F9/6541 , C07F9/6558 , C07F9/40 , A61K31/675
CPC分类号： C07F9/6541 , A61K31/675 , C07F9/4056 , C07F9/65583 , C07F9/65586
摘要： Benzothiazole phosphonate analogs and methods of using the same to inhibit the activity of Amyloid Binding Alcohol Dehydrogenase and in the amelioration or treatment of Alzheimer's disease are provided.
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3.发明申请公开(公告)号：US20160263133A1
公开(公告)日：2016-09-15
申请号：US15163275
申请日：2016-05-24
申请人： University of Kansas
发明人： ShiDu Yan , Koteswara Rao Valasani
IPC分类号： A61K31/675
CPC分类号： C07F9/6541 , A61K31/675 , C07F9/4056 , C07F9/65583 , C07F9/65586
摘要： Benzothiazole phosphonate analogs and methods of using the same to inhibit the activity of Amyloid Binding Alcohol Dehydrogenase and in the amelioration or treatment of Alzheimer's disease are provided.
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4.发明授权Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease 有权膦酸酯衍生物及其在治疗阿尔茨海默病中的用途公开(公告)号：US09346839B2
公开(公告)日：2016-05-24
申请号：US14539050
申请日：2014-11-12
申请人： University of Kansas
发明人： ShiDu Yan , Koteswara Rao Valasani
IPC分类号： C07F9/54 , C07F9/40 , C07F9/6558 , C07F9/6541
CPC分类号： C07F9/6541 , A61K31/675 , C07F9/4056 , C07F9/65583 , C07F9/65586
摘要： Benzothiazole phosphonate analogs and methods of using the same to inhibit the activity of Amyloid Binding Alcohol Dehydrogenase and in the amelioration or treatment of Alzheimer's disease are provided.
摘要翻译： 提供了苯并噻唑膦酸酯类似物及其用于抑制淀粉样蛋白结合醇脱氢酶活性和改善或治疗阿尔茨海默病的方法。
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公开(公告)号：US09738615B2
公开(公告)日：2017-08-22
申请号：US14851835
申请日：2015-09-11
IPC分类号： A61K31/426 , C07D277/56 , C07D513/04
CPC分类号： C07D277/56 , C07D513/04
摘要： A compound that can function as a Cyclophilin D can include a structure of Formula 1 or Formula 2 or Formula 3 or Formula 4 or Formula 5 or Formula 6 or Formula 7 or Formula 8, derivative thereof, prodrug thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof, as presented herein. The Cyclophilin D inhibitors can inhibit onset or treat neurodegenerative disease, such as Alzheimer's disease, or can be used for inhibiting progression or treating diabetes. An example of such a compound is provided by Formula 1A
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6.发明申请PHOSPHONATE DERIVATIVES AND METHODS OF USE THEREOF IN THE TREATMENT OF ALZHEIMER'S DISEASE 有权磷酸氢盐衍生物及其在治疗阿尔茨海默病中的应用方法公开(公告)号：US20150065463A1
公开(公告)日：2015-03-05
申请号：US14539050
申请日：2014-11-12
申请人： University of Kansas
发明人： ShiDu Yan , Koteswara Rao Valasani
IPC分类号： C07F9/54
CPC分类号： C07F9/6541 , A61K31/675 , C07F9/4056 , C07F9/65583 , C07F9/65586
摘要： Benzothiazole phosphonate analogs and methods of using the same to inhibit the activity of Amyloid Binding Alcohol Dehydrogenase and in the amelioration or treatment of Alzheimer's disease are provided.
摘要翻译： 提供了苯并噻唑膦酸酯类似物及其用于抑制淀粉样蛋白结合醇脱氢酶活性和改善或治疗阿尔茨海默病的方法。
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