公开(公告)号：US20210317067A1

公开(公告)日：2021-10-14

申请号：US17280235

申请日：2019-09-30

Applicant: University of Kansas

Inventor： Russell Swerdlow ,  Laird Forrest ,  Jordan Hunt ,  Heather Wilkins ,  Eli Michaelis

IPC: C07C69/716 ,  A61P25/28

Abstract: Compounds, compositions, and methods related to bioenergetic metabolism are provided. The compounds and com positions are suited to promote bioenergetic processes including cellular respiration and glycolytic flux and may be used to treat mitochondrial disorders, neurodegenerative diseases (such as Alzheimer's disease (AD), Parkinson's disease, and/or amyotrophic lateral sclerosis), multiple sclerosis, and/or epilepsy.

公开(公告)号：US11952337B2

公开(公告)日：2024-04-09

申请号：US17745773

申请日：2022-05-16

Applicant: University of Kansas

Inventor： Russell Swerdlow ,  Laird Forrest ,  Jordan Hunt ,  Heather Wilkins ,  Eli Michaelis

IPC: C07C69/716 ,  A61P25/28

CPC classification number: C07C69/716 ,  A61P25/28

Abstract: Compounds, compositions, and methods related to bioenergetic metabolism are provided. The compounds and compositions are suited to promote bioenergetic processes including cellular respiration and glycolytic flux and may be used to treat mitochondrial disorders, neurodegenerative diseases (such as Alzheimer's disease (AD), Parkinson's disease, and/or amyotrophic lateral sclerosis), multiple sclerosis, and/or epilepsy.

公开(公告)号：US11045556B2

公开(公告)日：2021-06-29

申请号：US16063061

申请日：2016-12-16

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  THE UNIVERSITY OF KANSAS

Inventor： Steven R. Buchman ,  Mark Cohen ,  Alexis Donneys ,  Noah Nelson ,  Laird Forrest ,  Ti Zhang ,  Qiuhong Yang

IPC: A61K47/69 ,  A61P19/00 ,  A61P19/08 ,  A61K9/51 ,  A61L27/50 ,  A61K47/61 ,  A61K31/16 ,  A61L27/20 ,  A61L27/54 ,  A61L27/58

Abstract: The present invention relates to novel therapeutic nanoparticles. In particular, the present invention is directed to nanoparticles associated (e.g., complexed, conjugated, encapsulated, absorbed, adsorbed, admixed) with angiogenesis-activating-agents, methods of synthesizing the same, devices or compositions comprising such nanoparticles, as well as systems and methods utilizing the nanoparticles (e.g., in therapeutic settings for enhancing and/or activating angiogenesis at targeted tissue region).

公开(公告)号：US20220177472A1

公开(公告)日：2022-06-09

申请号：US17598160

申请日：2020-04-16

Applicant: UNIVERSITY OF KANSAS ,  HYLAPHARM, LLC

Inventor： Laird Forrest ,  Daniel Aires ,  Ryan Moulder ,  Ruolin Lu ,  Jordan Hunt ,  Peter Kleindl ,  Ti Zhang ,  Chad Groer ,  Shuang Cai

IPC: C07D471/04 ,  A61K47/61 ,  A61P35/00 ,  A61P29/00

Abstract: The present technology is directed to TLR7 and TLR8 agonist compounds, compositions, and methods of using the same for the treatment of cancers and as vaccine adjuvants.

公开(公告)号：US20200330507A1

公开(公告)日：2020-10-22

申请号：US16850748

申请日：2020-04-16

Applicant: University of Kansas ,  HylaPharm, LLC

Inventor： Laird Forrest ,  Daniel Aires ,  Ryan Moulder ,  Ruolin Lu ,  Jordan Hunt ,  Peter Kleindl ,  Ti Zhang ,  Chad Groer ,  Shuang Cai

IPC: A61K33/243 ,  C07F15/00 ,  A61K47/36 ,  A61K45/06 ,  A61P35/00

Abstract: Provided are platinum(IV) compounds of Formula I or pharmaceutically acceptable salts thereof. Also provided are compositions including such compounds as well as methods of using the same.

公开(公告)号：US12295970B2

公开(公告)日：2025-05-13

申请号：US17598160

申请日：2020-04-16

Applicant: UNIVERSITY OF KANSAS ,  HYLAPHARM, LLC

Inventor： Laird Forrest ,  Daniel Aires ,  Ryan Moulder ,  Ruolin Lu ,  Jordan Hunt ,  Peter Kleindl ,  Ti Zhang ,  Chad Groer ,  Shuang Cai

IPC: A61K33/243 ,  A61K45/06 ,  A61K47/36 ,  A61K47/61 ,  A61P29/00 ,  A61P35/00 ,  C07D471/04 ,  C07F15/00

Abstract: The present technology is directed to TLR7 and TLR8 agonist compounds, compositions, and methods of using the same for the treatment of cancers and as vaccine adjuvants.

公开(公告)号：US11458163B2

公开(公告)日：2022-10-04

申请号：US16850748

申请日：2020-04-16

Applicant: University of Kansas ,  HylaPharm, LLC

Inventor： Laird Forrest ,  Daniel Aires ,  Ryan Moulder ,  Ruolin Lu ,  Jordan Hunt ,  Peter Kleindl ,  Ti Zhang ,  Chad Groer ,  Shuang Cai

IPC: A61K33/243 ,  C07F15/00 ,  A61P35/00 ,  A61K45/06 ,  A61K47/36

Abstract: Provided are platinum(IV) compounds of Formula I or pharmaceutically acceptable salts thereof. Also provided are compositions including such compounds as well as methods of using the same.

公开(公告)号：US11332432B2

公开(公告)日：2022-05-17

申请号：US17280235

申请日：2019-09-30

Applicant: University of Kansas

Inventor： Russell Swerdlow ,  Laird Forrest ,  Jordan Hunt ,  Heather Wilkins ,  Eli Michaelis

IPC: C07C69/716 ,  A61P25/28

Abstract: Compounds, compositions, and methods related to bioenergetic metabolism are provided. The compounds and com positions are suited to promote bioenergetic processes including cellular respiration and glycolytic flux and may be used to treat mitochondrial disorders, neurodegenerative diseases (such as Alzheimer's disease (AD), Parkinson's disease, and/or amyotrophic lateral sclerosis), multiple sclerosis, and/or epilepsy.