公开(公告)号：US09676818B2

公开(公告)日：2017-06-13

申请号：US14761805

申请日：2014-01-17

Applicant: University of Kansas

Inventor： Deepak B. Salunke ,  Xiaoqiang Guo ,  Sunil A. David

IPC: A61K38/00 ,  C07K5/068 ,  A61K39/39 ,  C07K14/705 ,  C07K5/062 ,  A61K39/00

CPC classification number: C07K5/06086 ,  A61K38/00 ,  A61K39/39 ,  A61K2039/55516 ,  C07K5/0606 ,  C07K14/705

Abstract: The present disclosure is directed to a novel class of toll-like receptor 2-agonistic (TLR2) lipopeptide compounds having specific structures, and synthetic methods of making the compounds. These compounds provide high potency of agonistic activities with human, other than murine, TLR2, and are useful as vaccine adjuvants. Vaccines are perhaps one of the most successful medical interventions against infectious disease.

公开(公告)号：US20150337009A1

公开(公告)日：2015-11-26

申请号：US14761805

申请日：2014-01-17

Applicant: UNIVERSITY OF KANSAS

Inventor： Deepak B. Salunke ,  Xiaoqiang Guo ,  Sunil A. David

IPC: C07K5/068 ,  A61K39/39

CPC classification number: C07K5/06086 ,  A61K38/00 ,  A61K39/39 ,  A61K2039/55516 ,  C07K5/0606 ,  C07K14/705

Abstract: The present disclosure is directed to a novel class of toll-like receptor 2-agonistic (TLR2) lipopeptide compounds having specific structures, and synthetic methods of making the compounds. These compounds provide high potency of agonistic activities with human, other than murine, TLR2, and are useful as vaccine adjuvants. Vaccines are perhaps one of the most successful medical interventions against infectious disease.

Abstract translation: 本公开涉及具有特定结构的新一类类型的toll样受体2-激动（TLR2）脂肽化合物，以及制备该化合物的合成方法。 这些化合物与除了鼠TLR2以外的人具有很强的激动活性，并且可用作疫苗佐剂。 疫苗可能是抗传染病最成功的医疗措施之一。