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公开(公告)号：US20210035672A1
公开(公告)日：2021-02-04
申请号：US17044097
申请日：2019-04-05
发明人： Jogarao Gobburu , Vijay Ivaturi
摘要： Techniques for generating a dosing protocol for an individual include a continuous multivariate model for dose response to a medicament, the model having a population parameter that characterizes a population of individuals and a random parameter based on a distribution of observed values in the population. A first dose based on a naive most probable value for the random parameter; a probability that the first dose is therapeutic; and, a set of one or more times to sample the subject for the therapeutic effect based on the probability, are all determined using the model. The subject is sampled to obtain measured values of the therapeutic effect. A subject-specific most probable value for the at least one random parameter is determined based on the model and measured values. A second dose and timing therefor are determined based on the subject-specific most probable value.
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公开(公告)号：US20190380605A1
公开(公告)日：2019-12-19
申请号：US16549620
申请日：2019-08-23
发明人： Vijay Ivaturi , Jogarao Gobburu
摘要： Embodiments of the invention are broadly drawn to methods for determining an optimum dose of an antiarrhythmic drug, for example sotalol. In particular, the method involves titrating the dose of the drug gradually to determine the optimum plasma concentration for a patient, whether the patient has normal or abnormal renal function.
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公开(公告)号：US20210076959A1
公开(公告)日：2021-03-18
申请号：US17003297
申请日：2020-08-26
发明人： Vijay Ivaturi , Jogarao Gobburu
摘要： Embodiments of the invention are broadly drawn to methods for determining an optimum dose of an antiarrhythmic drug, for example sotalol. In particular, the method involves titrating the dose of the drug gradually to determine the optimum plasma concentration for a patient, whether the patient has normal or abnormal renal function.
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公开(公告)号：US10799138B2
公开(公告)日：2020-10-13
申请号：US16376706
申请日：2019-04-05
发明人： Vijay Ivaturi , Jogarao Gobburu
摘要： Embodiments of the invention are broadly drawn to methods for determining an optimum dose of an antiarrhythmic drug, for example sotalol. In particular, the method involves titrating the dose of the drug gradually to determine the optimum plasma concentration for a patient, whether the patient has normal or abnormal renal function.
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公开(公告)号：US20230225664A1
公开(公告)日：2023-07-20
申请号：US18156092
申请日：2023-01-18
发明人： Vijay Ivaturi , Jogarao Gobburu
CPC分类号： A61B5/361 , G16H50/30 , A61K9/0019 , A61K31/18 , A61K9/0053
摘要： Embodiments of the invention are broadly drawn to methods for determining an optimum dose of an antiarrhythmic drug, for example sotalol. In particular, the method involves titrating the dose of the drug gradually to determine the optimum plasma concentration for a patient, whether the patient has normal or abnormal renal function.
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公开(公告)号：US11583216B2
公开(公告)日：2023-02-21
申请号：US17003297
申请日：2020-08-26
发明人： Vijay Ivaturi , Jogarao Gobburu
摘要： Embodiments of the invention are broadly drawn to methods for determining an optimum dose of an antiarrhythmic drug, for example sotalol. In particular, the method involves titrating the dose of the drug gradually to determine the optimum plasma concentration for a patient, whether the patient has normal or abnormal renal function.
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公开(公告)号：US20190307343A1
公开(公告)日：2019-10-10
申请号：US16376706
申请日：2019-04-05
发明人： Vijay Ivaturi , Jogarao Gobburu
摘要： Embodiments of the invention are broadly drawn to methods for determining an optimum dose of an antiarrhythmic drug, for example sotalol. In particular, the method involves titrating the dose of the drug gradually to determine the optimum plasma concentration for a patient, whether the patient has normal or abnormal renal function.
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