公开(公告)号：US20190142968A1

公开(公告)日：2019-05-16

申请号：US16091675

申请日：2017-04-05

Applicant: University of Massachusetts

Inventor： Gyongyi Szabo ,  Guangping Gao ,  Abhishek Satishchandran

IPC: A61K48/00 ,  A61K31/7105 ,  A61P1/16 ,  A61K9/00 ,  A61K47/68 ,  C12N5/071

Abstract: In some aspects, the disclosure relates to methods and compositions for modulation of miR-122 expression in a cell or a subject. In some embodiments, methods and compositions described by the disclosure are useful for the treatment of liver-associated diseases (e.g., chronic liver disease, alcoholic liver disease).

公开(公告)号：US11207426B2

公开(公告)日：2021-12-28

申请号：US16091675

申请日：2017-04-05

Applicant: University of Massachusetts

Inventor： Gyongyi Szabo ,  Guangping Gao ,  Abhishek Satishchandran

IPC: C12N15/11 ,  A61K48/00 ,  A61K31/7105 ,  A61K9/00 ,  C12N15/113 ,  A61K31/713 ,  A61K47/68 ,  A61P1/16 ,  C12N5/071

Abstract: In some aspects, the disclosure relates to methods and compositions for modulation of miR-122 expression in a cell or a subject. In some embodiments, methods and compositions described by the disclosure are useful for the treatment of liver-associated diseases (e.g., chronic liver disease, alcoholic liver disease).