公开(公告)号：US20190300904A1

公开(公告)日：2019-10-03

申请号：US16341504

申请日：2017-10-13

Applicant: University of Massachusetts

Inventor： Guangping Gao ,  Guangchao Xu ,  Phillip Tai ,  Yuquan Wei ,  Li Luo

IPC: C12N15/86 ,  C07K14/005 ,  A61K35/761 ,  A01K67/027

Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

公开(公告)号：US20230374545A1

公开(公告)日：2023-11-23

申请号：US18150477

申请日：2023-01-05

Applicant: University of Massachusetts ,  Sichuan University

Inventor： Guangping Gao ,  Guangchao Xu ,  Phillip Tai ,  Yuquan Wei ,  Li Luo

IPC: C12N15/86 ,  C12N15/861 ,  C07K14/005 ,  C07K14/015 ,  A61K35/761 ,  A01K67/027 ,  A61K48/00

CPC classification number: C12N15/86 ,  C12N15/861 ,  C07K14/005 ,  C07K14/015 ,  A61K35/761 ,  A01K67/0275 ,  C12N2750/14122 ,  C12N2750/14123 ,  A01K2267/03 ,  A01K2217/05 ,  A61K48/00 ,  C12N2750/14143 ,  C12N2750/14145

Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

公开(公告)号：US11578340B2

公开(公告)日：2023-02-14

申请号：US16341504

申请日：2017-10-13

Applicant: University of Massachusetts ,  Sichuan University

Inventor： Guangping Gao ,  Guangchao Xu ,  Phillip Tai ,  Yuquan Wei ,  Li Luo

IPC: C12N15/86 ,  A01K67/027 ,  A61K35/761 ,  C07K14/005 ,  C12N15/861 ,  C07K14/015 ,  A61K48/00

Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

公开(公告)号：US20230138766A1

公开(公告)日：2023-05-04

申请号：US17915548

申请日：2021-03-30

Applicant: University of Massachusetts ,  Sichuan University

Inventor： Guangping Gao ,  Guangchao Xu ,  Phillip Tai ,  Yuquan Wei ,  Li Luo

IPC: C12N15/86 ,  A61K9/00 ,  C07K14/005

Abstract: Aspects of the disclosure relate to compositions and methods for delivering a transgene (e.g., a transgene encoding one or more gene products) to a target cell. The disclosure is based, in part, on adeno-associated virus (AAV) capsid protein variants characterized by tropisms for certain cell types (e.g., neurons, muscle cells, bone cells, heart cells, etc.). In some embodiments, recombinant A A Vs (rAAVs) comprising the capsid protein variants (e.g., AAVv66, SEQ ID NO: 1) are more efficiently packaged than rAAVs having certain wild-type AAV capsid proteins. Methods of delivering an rAAV comprising the AAV capsid protein variants are also described by the disclosure.

公开(公告)号：US20200316221A1

公开(公告)日：2020-10-08

申请号：US16842679

申请日：2020-04-07

Applicant: University of Massachusetts

Inventor： Guangping Gao ,  Guangchao Xu ,  Phillip Tai ,  Yuquan Wei ,  Li Luo

IPC: A61K48/00 ,  A61K9/00 ,  A61K35/76

Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associated viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.