公开(公告)号：US20210180031A1

公开(公告)日：2021-06-17

申请号：US17116168

申请日：2020-12-09

Applicant: University of Massachusetts

Inventor： Guangping Gao ,  Li Zhong

IPC: C12N7/00 ,  C12N15/864 ,  A61K38/17 ,  A61K48/00 ,  C12N15/113 ,  C12N15/86

Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

公开(公告)号：US10894949B2

公开(公告)日：2021-01-19

申请号：US16058938

申请日：2018-08-08

Applicant: University of Massachusetts

Inventor： Guangping Gao ,  Li Zhong

IPC: A61K48/00 ,  A61K38/17 ,  C12N15/113 ,  C12N15/86 ,  C12N7/00 ,  C12N15/864

Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

公开(公告)号：US20190085301A1

公开(公告)日：2019-03-21

申请号：US16058938

申请日：2018-08-08

Applicant: University of Massachusetts

Inventor： Guangping Gao ,  Li Zhong

IPC: C12N7/00 ,  A61K38/17 ,  A61K48/00 ,  C12N15/113 ,  C12N15/86

Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

公开(公告)号：US20170191039A1

公开(公告)日：2017-07-06

申请号：US15120294

申请日：2015-02-19

Applicant: University of Massachusetts

Inventor： Guangping Gao ,  Li Zhong

IPC: C12N7/00 ,  A61K38/17 ,  A61K48/00 ,  C12N15/86 ,  C12N15/113

CPC classification number: C12N7/00 ,  A61K38/1709 ,  A61K48/0058 ,  C12N15/113 ,  C12N15/86 ,  C12N2310/141 ,  C12N2710/10332 ,  C12N2710/10342 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14171

Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capab- lities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associate viruses. IN some as- pects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.

公开(公告)号：US10072251B2

公开(公告)日：2018-09-11

申请号：US15120294

申请日：2015-02-19

Applicant: University of Massachusetts

Inventor： Guangping Gao ,  Li Zhong

IPC: C12N15/113 ,  C12N7/00 ,  C12N15/86 ,  A61K48/00 ,  A61K38/17

CPC classification number: C12N7/00 ,  A61K38/1709 ,  A61K48/0058 ,  C12N15/113 ,  C12N15/86 ,  C12N2310/141 ,  C12N2710/10332 ,  C12N2710/10342 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14171

Abstract: The disclosure in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the disclosure relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the disclosure relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.