公开(公告)号：US20240207441A1

公开(公告)日：2024-06-27

申请号：US18288216

申请日：2022-04-26

Applicant: University of Massachusetts

Inventor： Yukiko Maeda ,  Phillip Tai ,  Guangping Gao

IPC: A61K48/00 ,  C07K14/005 ,  C12N15/86

CPC classification number: A61K48/0041 ,  A61K48/0075 ,  C07K14/005 ,  C12N15/86 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14145

Abstract: Aspects of the disclosure relate to compositions and methods for delivering a transgene (e.g., an anti-inflammatory transgene encoding one or more gene products) to a joint. The disclosure is based, in part, on adeno-associated virus (AAV) capsid protein variants characterized by tropisms for joint tissues (e.g., cartilage, skin, muscle, and bone cells). Methods of treating arthritis in a joint by administering an rAAV comprising the AAV capsid protein variants are also described by the disclosure.