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公开(公告)号:US10731178B2
公开(公告)日:2020-08-04
申请号:US15613646
申请日:2017-06-05
Applicant: University of Massachusetts
Inventor: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC: C12N15/86 , A61K48/00 , C12N15/113 , C12N15/864 , A61K38/50 , A61K31/713 , C12N9/80 , A61P25/00 , C12N7/00 , C12N15/63
Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US20190194688A1
公开(公告)日:2019-06-27
申请号:US16234819
申请日:2018-12-28
Applicant: University of Massachusetts
Inventor: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC: C12N15/86 , A61K31/713 , A61K38/50 , C12N7/00 , A61K48/00 , C12N9/80 , C12N15/864 , C12N15/113
CPC classification number: C12N15/86 , A61K31/713 , A61K38/50 , A61K48/00 , A61K48/0058 , A61K48/0075 , A61P25/00 , C12N7/00 , C12N9/80 , C12N15/1137 , C12N15/635 , C12N15/8645 , C12N2310/141 , C12N2750/14133 , C12N2750/14141 , C12N2750/14143 , C12N2750/14145 , C12N2750/14162 , C12N2810/10 , C12N2840/007 , C12Y305/01015
Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US20190276849A1
公开(公告)日:2019-09-12
申请号:US16365065
申请日:2019-03-26
Applicant: University of Massachusetts
Inventor: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC: C12N15/86 , A61K38/50 , C12N7/00 , A61K48/00 , C12N9/80 , C12N15/864 , C12N15/113 , A61K31/713
Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US20190194689A1
公开(公告)日:2019-06-27
申请号:US16234834
申请日:2018-12-28
Applicant: University of Massachusetts
Inventor: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC: C12N15/86 , A61K31/713 , A61K38/50 , C12N7/00 , A61K48/00 , C12N9/80 , C12N15/864 , C12N15/113
CPC classification number: C12N15/86 , A61K31/713 , A61K38/50 , A61K48/00 , A61K48/0058 , A61K48/0075 , A61P25/00 , C12N7/00 , C12N9/80 , C12N15/1137 , C12N15/635 , C12N15/8645 , C12N2310/141 , C12N2750/14133 , C12N2750/14141 , C12N2750/14143 , C12N2750/14145 , C12N2750/14162 , C12N2810/10 , C12N2840/007 , C12Y305/01015
Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US09701984B2
公开(公告)日:2017-07-11
申请号:US14445670
申请日:2014-07-29
Applicant: University of Massachusetts
Inventor: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC: A61K31/713 , A61K48/00 , C12N15/113 , C12N15/864 , C12N15/86 , A61K38/50 , C12N9/80 , C12N7/00 , C12N15/63
CPC classification number: C12N15/86 , A61K31/713 , A61K38/50 , A61K48/00 , A61K48/0058 , A61K48/0075 , C12N7/00 , C12N9/80 , C12N15/1137 , C12N15/635 , C12N15/8645 , C12N2310/141 , C12N2750/14133 , C12N2750/14141 , C12N2750/14143 , C12N2750/14145 , C12N2750/14162 , C12N2810/10 , C12N2840/007 , C12Y305/01015
Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US20230332179A1
公开(公告)日:2023-10-19
申请号:US18053407
申请日:2022-11-08
Applicant: University of Massachusetts
Inventor: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC: C12N15/86 , C12N15/864 , C12N15/113 , A61K38/50 , A61K31/713 , A61K48/00 , C12N9/80 , A61P25/00 , C12N7/00
CPC classification number: C12N15/86 , C12N15/8645 , C12N15/1137 , A61K38/50 , A61K31/713 , A61K48/0075 , C12N9/80 , C12Y305/01015 , A61P25/00 , C12N7/00 , A61K48/0058 , C12N2750/14143 , C12N2750/14145 , C12N2750/14162 , C12N2810/10 , C12N2840/007 , C12N15/635
Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US20190276848A1
公开(公告)日:2019-09-12
申请号:US16364763
申请日:2019-03-26
Applicant: University of Massachusetts
Inventor: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC: C12N15/86 , A61K38/50 , C12N7/00 , A61K48/00 , C12N9/80 , C12N15/864 , C12N15/113 , A61K31/713
Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US20180148738A9
公开(公告)日:2018-05-31
申请号:US15613646
申请日:2017-06-05
Applicant: University of Massachusetts
Inventor: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC: C12N15/86 , C12N15/864 , A61K38/50 , A61K48/00 , C12N7/00 , C12N9/80 , C12N15/113 , A61K31/713 , C12N15/63
Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US20170349911A1
公开(公告)日:2017-12-07
申请号:US15613646
申请日:2017-06-05
Applicant: University of Massachusetts
Inventor: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC: C12N15/86 , A61K38/50 , A61K48/00 , C12N9/80 , C12N15/113 , A61K31/713 , C12N15/864 , C12N7/00 , C12N15/63
Abstract: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US09663586B2
公开(公告)日:2017-05-30
申请号:US14811102
申请日:2015-07-28
Applicant: University of Massachusetts
Inventor: Donna Ambrosino , Gregory Babcock , Teresa Broering , Zuoshang Xu
IPC: C07K16/40 , A61K39/395 , C07H21/04 , C12N15/63 , C12N15/13 , C12N5/12 , A61K47/48 , A61K31/428 , A61K45/06 , A61K39/00
CPC classification number: C07K16/40 , A61K31/428 , A61K39/3955 , A61K45/06 , A61K47/6871 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: The present invention features anti-SOD1 antibodies and methods of using the antibodies for the treatment of amyotrophic lateral sclerosis (ALS) or the amelioration of symptoms associated with ALS.
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