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公开(公告)号:US10731178B2
公开(公告)日:2020-08-04
申请号:US15613646
申请日:2017-06-05
发明人: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC分类号: C12N15/86 , A61K48/00 , C12N15/113 , C12N15/864 , A61K38/50 , A61K31/713 , C12N9/80 , A61P25/00 , C12N7/00 , C12N15/63
摘要: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US20190194688A1
公开(公告)日:2019-06-27
申请号:US16234819
申请日:2018-12-28
发明人: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC分类号: C12N15/86 , A61K31/713 , A61K38/50 , C12N7/00 , A61K48/00 , C12N9/80 , C12N15/864 , C12N15/113
CPC分类号: C12N15/86 , A61K31/713 , A61K38/50 , A61K48/00 , A61K48/0058 , A61K48/0075 , A61P25/00 , C12N7/00 , C12N9/80 , C12N15/1137 , C12N15/635 , C12N15/8645 , C12N2310/141 , C12N2750/14133 , C12N2750/14141 , C12N2750/14143 , C12N2750/14145 , C12N2750/14162 , C12N2810/10 , C12N2840/007 , C12Y305/01015
摘要: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US20190276848A1
公开(公告)日:2019-09-12
申请号:US16364763
申请日:2019-03-26
发明人: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC分类号: C12N15/86 , A61K38/50 , C12N7/00 , A61K48/00 , C12N9/80 , C12N15/864 , C12N15/113 , A61K31/713
摘要: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US20180148738A9
公开(公告)日:2018-05-31
申请号:US15613646
申请日:2017-06-05
发明人: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC分类号: C12N15/86 , C12N15/864 , A61K38/50 , A61K48/00 , C12N7/00 , C12N9/80 , C12N15/113 , A61K31/713 , C12N15/63
摘要: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US20170349911A1
公开(公告)日:2017-12-07
申请号:US15613646
申请日:2017-06-05
发明人: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC分类号: C12N15/86 , A61K38/50 , A61K48/00 , C12N9/80 , C12N15/113 , A61K31/713 , C12N15/864 , C12N7/00 , C12N15/63
摘要: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US09663586B2
公开(公告)日:2017-05-30
申请号:US14811102
申请日:2015-07-28
发明人: Donna Ambrosino , Gregory Babcock , Teresa Broering , Zuoshang Xu
IPC分类号: C07K16/40 , A61K39/395 , C07H21/04 , C12N15/63 , C12N15/13 , C12N5/12 , A61K47/48 , A61K31/428 , A61K45/06 , A61K39/00
CPC分类号: C07K16/40 , A61K31/428 , A61K39/3955 , A61K45/06 , A61K47/6871 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The present invention features anti-SOD1 antibodies and methods of using the antibodies for the treatment of amyotrophic lateral sclerosis (ALS) or the amelioration of symptoms associated with ALS.
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公开(公告)号:US20140335054A1
公开(公告)日:2014-11-13
申请号:US14445670
申请日:2014-07-29
发明人: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
CPC分类号: C12N15/86 , A61K31/713 , A61K38/50 , A61K48/00 , A61K48/0058 , A61K48/0075 , C12N7/00 , C12N9/80 , C12N15/1137 , C12N15/635 , C12N15/8645 , C12N2310/141 , C12N2750/14133 , C12N2750/14141 , C12N2750/14143 , C12N2750/14145 , C12N2750/14162 , C12N2810/10 , C12N2840/007 , C12Y305/01015
摘要: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
摘要翻译: 本发明在一些方面涉及可用于靶向转基因到CNS组织的重组腺相关病毒,以及包含其的组合物及其使用方法。 在一些方面,本发明提供了用于治疗CNS相关疾病的方法和组合物。
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公开(公告)号:US20190276849A1
公开(公告)日:2019-09-12
申请号:US16365065
申请日:2019-03-26
发明人: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC分类号: C12N15/86 , A61K38/50 , C12N7/00 , A61K48/00 , C12N9/80 , C12N15/864 , C12N15/113 , A61K31/713
摘要: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US20190194689A1
公开(公告)日:2019-06-27
申请号:US16234834
申请日:2018-12-28
发明人: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC分类号: C12N15/86 , A61K31/713 , A61K38/50 , C12N7/00 , A61K48/00 , C12N9/80 , C12N15/864 , C12N15/113
CPC分类号: C12N15/86 , A61K31/713 , A61K38/50 , A61K48/00 , A61K48/0058 , A61K48/0075 , A61P25/00 , C12N7/00 , C12N9/80 , C12N15/1137 , C12N15/635 , C12N15/8645 , C12N2310/141 , C12N2750/14133 , C12N2750/14141 , C12N2750/14143 , C12N2750/14145 , C12N2750/14162 , C12N2810/10 , C12N2840/007 , C12Y305/01015
摘要: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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公开(公告)号:US09701984B2
公开(公告)日:2017-07-11
申请号:US14445670
申请日:2014-07-29
发明人: Guangping Gao , Hongwei Zhang , Hongyan Wang , Zuoshang Xu
IPC分类号: A61K31/713 , A61K48/00 , C12N15/113 , C12N15/864 , C12N15/86 , A61K38/50 , C12N9/80 , C12N7/00 , C12N15/63
CPC分类号: C12N15/86 , A61K31/713 , A61K38/50 , A61K48/00 , A61K48/0058 , A61K48/0075 , C12N7/00 , C12N9/80 , C12N15/1137 , C12N15/635 , C12N15/8645 , C12N2310/141 , C12N2750/14133 , C12N2750/14141 , C12N2750/14143 , C12N2750/14145 , C12N2750/14162 , C12N2810/10 , C12N2840/007 , C12Y305/01015
摘要: The invention in some aspects relates to recombinant adeno-associated viruses useful for targeting transgenes to CNS tissue, and compositions comprising the same, and methods of use thereof. In some aspects, the invention provides methods and compositions for treating CNS-related disorders.
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