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公开(公告)号：US09540454B2
公开(公告)日：2017-01-10
申请号：US14565671
申请日：2014-12-10
发明人： Michio Muguruma , Hiroshi Murata
IPC分类号： A61K31/726 , A61K31/70 , C08B37/00 , A61K31/727 , G01N30/14
CPC分类号： C08B37/0075 , A61K31/727 , C08B37/0003 , C08B37/0078 , G01N30/14 , Y10T436/14 , Y10T436/142222 , Y10T436/143333
摘要： The present invention provides a high purity heparin useful to be a pharmaceutical product, cosmetics, research reagent, or the like, and a method for producing the same, more specifically, a heparin which does not substantially contain a nitrous acid degradation-resistant impurity and a method for producing a heparin, comprising mixing an aqueous solution of 5 to 30% by weight of the heparin with ethanol having an amount (volume) 0.2 to 1 times the amount (volume) of the aqueous heparin solution to obtain a colloidal precipitate of heparin.
摘要翻译： 本发明提供了可用作药物，化妆品，研究试剂等的高纯度肝素及其制造方法，更具体而言，是基本上不含有亚硝酸降解性杂质的肝素， 一种肝素的制造方法，其特征在于，将5〜30重量％的肝素水溶液与乙醇配合（体积）为肝素水溶液的量（体积）的0.2〜1倍，得到胶体沉淀物 肝素。
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公开(公告)号：US20150094460A1
公开(公告)日：2015-04-02
申请号：US14565671
申请日：2014-12-10
发明人： Michio Muguruma , Hiroshi Murata
IPC分类号： C08B37/00
CPC分类号： C08B37/0075 , A61K31/727 , C08B37/0003 , C08B37/0078 , G01N30/14 , Y10T436/14 , Y10T436/142222 , Y10T436/143333
摘要： The present invention provides a high purity heparin useful to be a pharmaceutical product, cosmetics, research reagent, or the like, and a method for producing the same, more specifically, a heparin which does not substantially contain a nitrous acid degradation-resistant impurity and a method for producing a heparin, comprising mixing an aqueous solution of 5 to 30% by weight of the heparin with ethanol having an amount (volume) 0.2 to 1 times the amount (volume) of the aqueous heparin solution to obtain a colloidal precipitate of heparin.
摘要翻译： 本发明提供了可用作药物，化妆品，研究试剂等的高纯度肝素及其制造方法，更具体而言，是基本上不含有亚硝酸降解性杂质的肝素， 一种肝素的制造方法，其特征在于，将5〜30重量％的肝素水溶液与乙醇配合（体积）为肝素水溶液的量（体积）的0.2〜1倍，得到胶体沉淀物 肝素。
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