专利检索 ap:("University of Pittsburgh—Of the Commonwealth System of Higher Education") AND inv:"Cynthia St. Hilaire" 第 1 页

1.

发明授权
Genetically modified mesenchymal stem cells for use in cardiovascular prosthetics 有权

公开(公告)号：US11634716B2

公开(公告)日：2023-04-25

申请号：US16755717

申请日：2018-10-15

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Cynthia St. Hilaire

IPC分类号： C12N15/113 , C12N5/0775 , A61L27/38 , C12N15/86

摘要： A cardiovascular graft is provided, such as a prosthetic heart valve or blood vessel, that comprises mesenchymal stem cells (MSCs) and/or progeny thereof, modified to knock down or knockout expression of the telomerases reverse transcriptase gene (TERT), or otherwise reduce activity of TERT. Also provided are a method of making the cardiovascular graft, and a method of implanting the cardiovascular graft.

2.

发明申请
Genetically Modified Mesenchymal Stem Cells for Use in Cardiovascular Prosthetics 有权

公开(公告)号：US20210403915A1

公开(公告)日：2021-12-30

申请号：US16755717

申请日：2018-10-15

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Cynthia St. Hilaire

IPC分类号： C12N15/113 , C12N15/86 , C12N5/0775 , A61L27/38

摘要： A cardiovascular graft is provided, such as a prosthetic heart valve or blood vessel, that comprises mesenchymal stem cells (MSCs) and/or progeny thereof, modified to knock down or knockout expression of the telomerases reverse transcriptase gene (TERT), or otherwise reduce activity of TERT. Also provided are a method of making the cardiovascular graft, and a method of implanting the cardiovascular graft.