公开(公告)号：US09546144B2

公开(公告)日：2017-01-17

申请号：US14880862

申请日：2015-10-12

申请人： University of Pittsburgh—of the Commonwealth System of Higher Education

发明人： Peter Wipf ,  Joel S. Greenberger ,  Michael W. Epperly ,  Melissa M. Sprachman ,  Julie Pamela Goff

IPC分类号： A61K38/06 ,  A61K38/07 ,  C07D305/06 ,  C07D405/14 ,  C07D405/12 ,  C07K5/087 ,  C07K5/065 ,  C07D205/04 ,  C07K5/097

CPC分类号： C07D305/06 ,  C07D205/04 ,  C07D405/12 ,  C07D405/14 ,  C07K5/06078 ,  C07K5/0812 ,  C07K5/0823

摘要： A compound having the formula: wherein X is S, SO or SO2; one of R1, R2, and R3 is O and the others of R1, R2 and R3 are independently, the same or different, CH2, or CR13 wherein, R13 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)mOR15, wherein R15 is an alkyl group or an aryl group and m is an integer in the range of 1 to 10, and one of R5, R6, and R7 is O and the others of R5, R6 and R7 are independently, the same or different, CH2, or CR14 wherein, R14 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)nOR16, wherein R16 is an alkyl group or an aryl group and n is an integer in the range of 1 to 10; R4 and R8 are independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heteroaryl group, a C1-C3 alkoxy group, an aryloxy group, or —(CH2)qOR17, wherein R17 is an alkyl group or an aryl group and q is an integer in the range of 1 to 10, provided that R4 is not a C1-C3 alkoxy group or an aryloxy group when R1 or R3 is O and R8 is not a C1-C3 alkoxy group or an aryloxy group when R5 or R7 is O; R9, R10, R11 and R12 are independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, or an aryl group.

摘要翻译： 具有下式的化合物：其中X是S，SO或SO 2; R 1，R 2和R 3中的一个为O，R 1，R 2和R 3中的一个独立地为相同或不同的CH 2或CR 13，其中R 13为烷基，烯基，炔基，三烷基甲硅烷基 或 - （CH 2）m OR 15，其中R 15是烷基或芳基，m是1至10的整数，R 5，R 6和R 7中的一个是O，而其中R 5，R 6和 R7独立地相同或不同，CH2或CR14，其中R14是烷基，烯基，炔基，三烷基甲硅烷基或 - （CH2）nOR16，其中R16是烷基或芳基 n为1〜10的整数， R4和R8独立地相同或不同，为氢，烷基，烯基，炔基，芳基，杂芳基，C1-C3烷氧基，芳氧基或 - （CH2）qOR17 其中R 17为烷基或芳基，q为1〜10的整数，条件是当R 1或R 3为O时，R 4不为C 1 -C 3烷氧基或芳氧基，且R 8不为 当R 5或R 7为O时，C 1 -C 3烷氧基或芳氧基; R 9，R 10，R 11和R 12独立地为相同或不同的H，烷基，烯基，炔基或芳基。

公开(公告)号：US09200035B2

公开(公告)日：2015-12-01

申请号：US14352891

申请日：2012-10-19

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Peter Wipf ,  Joel S. Greenberger ,  Michael W. Epperly ,  Melissa M. Sprachman ,  Julie Pamela Goff

IPC分类号： A61K38/06 ,  A61K38/07 ,  C07K5/087 ,  C07D405/14 ,  C07D405/12 ,  C07D305/06 ,  C07K5/065 ,  C07D205/04

CPC分类号： C07D305/06 ,  C07D205/04 ,  C07D405/12 ,  C07D405/14 ,  C07K5/06078 ,  C07K5/0812 ,  C07K5/0823

摘要： A compound having the formula: wherein X is S, SO or SO2; one of R1, R2, and R3 is O and the others of R1, R2 and R3 are independently, the same or different, CH2, or CR13 wherein, R13 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)mOR15, wherein R15 is an alkyl group or an aryl group and m is an integer in the range of 1 to 10, and one of R5, R6, and R7 is O and the others of R5, R6 and R7 are independently, the same or different, CH2, or CR14 wherein, R14 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)nOR16, wherein R16 is an alkyl group or an aryl group and n is an integer in the range of 1 to 10; R4 and R8 are independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heteroaryl group, a C1-C3 alkoxy group, an aryloxy group, or —(CH2)qOR17, wherein R17 is an alkyl group or an aryl group and q is an integer in the range of 1 to 10, provided that R4 is not a C1-C3 alkoxy group or an aryloxy group when R1 or R3 is O and R8 is not a C1-C3 alkoxy group or an aryloxy group when R5 or R7 is O; R9, R10, R11 and R12 are independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, or an aryl group.

摘要翻译： 具有下式的化合物：其中X是S，SO或SO 2; R 1，R 2和R 3中的一个为O，R 1，R 2和R 3中的一个独立地为相同或不同的CH 2或CR 13，其中R 13为烷基，烯基，炔基，三烷基甲硅烷基 或 - （CH 2）m OR 15，其中R 15是烷基或芳基，m是1至10的整数，R 5，R 6和R 7中的一个是O，而其中R 5，R 6和 R7独立地相同或不同，CH2或CR14，其中R14是烷基，烯基，炔基，三烷基甲硅烷基或 - （CH2）nOR16，其中R16是烷基或芳基 n为1〜10的整数， R4和R8独立地相同或不同，为氢，烷基，烯基，炔基，芳基，杂芳基，C1-C3烷氧基，芳氧基或 - （CH2）qOR17 其中R 17为烷基或芳基，q为1〜10的整数，条件是当R 1或R 3为O时，R 4不为C 1 -C 3烷氧基或芳氧基，且R 8不为 当R 5或R 7为O时，C 1 -C 3烷氧基或芳氧基; R 9，R 10，R 11和R 12独立地为相同或不同的H，烷基，烯基，炔基或芳基。

公开(公告)号：US20140256654A1

公开(公告)日：2014-09-11

申请号：US14352891

申请日：2012-10-19

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Peter Wipf ,  Joel S. Greenberger ,  Michael W. Epperly ,  Melissa M. Sprachman ,  Julie Pamela Goff

IPC分类号： C07K5/087 ,  C07D205/04 ,  C07D405/12 ,  C07D305/06

CPC分类号： C07D305/06 ,  C07D205/04 ,  C07D405/12 ,  C07D405/14 ,  C07K5/06078 ,  C07K5/0812 ,  C07K5/0823

摘要： A compound having the formula: wherein X is S, SO or SO2; one of R1, R2, and R3 is O and the others of R1, R2 and R3 are independently, the same or different, CH2, or CR13 wherein, R13 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)mOR15, wherein R15 is an alkyl group or an aryl group and m is an integer in the range of 1 to 10, and one of R5, R6, and R7 is O and the others of R5, R6 and R7 are independently, the same or different, CH2, or CR14 wherein, R14 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)nOR16, wherein R16 is an alkyl group or an aryl group and n is an integer in the range of 1 to 10; R4 and R8 are independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heteroaryl group, a C1-C3 alkoxy group, an aryloxy group, or —(CH2)qOR17, wherein R17 is an alkyl group or an aryl group and q is an integer in the range of 1 to 10, provided that R4 is not a C1-C3 alkoxy group or an aryloxy group when R1 or R3 is O and R8 is not a C1-C3 alkoxy group or an aryloxy group when R5 or R7 is O; R9, R10, R11 and R12 are independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, or an aryl group.

摘要翻译： 具有下式的化合物：其中X是S，SO或SO 2; R 1，R 2和R 3中的一个为O，R 1，R 2和R 3中的一个独立地为相同或不同的CH 2或CR 13，其中R 13为烷基，烯基，炔基，三烷基甲硅烷基 或 - （CH 2）m OR 15，其中R 15是烷基或芳基，m是1至10的整数，R 5，R 6和R 7中的一个是O，而其中R 5，R 6和 R7独立地相同或不同，CH2或CR14，其中R14是烷基，烯基，炔基，三烷基甲硅烷基或 - （CH2）nOR16，其中R16是烷基或芳基 n为1〜10的整数， R4和R8独立地相同或不同，为氢，烷基，烯基，炔基，芳基，杂芳基，C1-C3烷氧基，芳氧基或 - （CH2）qOR17 其中R 17为烷基或芳基，q为1〜10的整数，条件是当R 1或R 3为O时，R 4不为C 1 -C 3烷氧基或芳氧基，且R 8不为 当R 5或R 7为O时，C 1 -C 3烷氧基或芳氧基; R 9，R 10，R 11和R 12独立地为相同或不同的H，烷基，烯基，炔基或芳基。

公开(公告)号：US20160176836A1

公开(公告)日：2016-06-23

申请号：US14880862

申请日：2015-10-12

申请人： University of Pittsburgh - of the Commonwealth System of Higher Education

发明人： Peter Wipf ,  Joel S. Greenberger ,  Michael W. Epperly ,  Melissa M. Sprachman ,  Julie Pamela Goff

IPC分类号： C07D305/06 ,  C07K5/097 ,  C07D405/12

CPC分类号： C07D305/06 ,  C07D205/04 ,  C07D405/12 ,  C07D405/14 ,  C07K5/06078 ,  C07K5/0812 ,  C07K5/0823

摘要： A compound having the formula: wherein X is S, SO or SO2; one of R1, R2, and R3 is O and the others of R1, R2 and R3 are independently, the same or different, CH2, or CR13 wherein, R13 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)mOR15, wherein R15 is an alkyl group or an aryl group and m is an integer in the range of 1 to 10, and one of R5, R6, and R7 is O and the others of R5, R6 and R7 are independently, the same or different, CH2, or CR14 wherein, R14 is an alkyl group, an alkenyl group, an alkynyl group, a trialkylsilyl group, or —(CH2)nOR16, wherein R16 is an alkyl group or an aryl group and n is an integer in the range of 1 to 10; R4 and R8 are independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heteroaryl group, a C1-C3 alkoxy group, an aryloxy group, or —(CH2)qOR17, wherein R17 is an alkyl group or an aryl group and q is an integer in the range of 1 to 10, provided that R4 is not a C1-C3 alkoxy group or an aryloxy group when R1 or R3 is O and R8 is not a C1-C3 alkoxy group or an aryloxy group when R5 or R7 is O; R9, R10, R11 and R12 are independently, the same or different, H, an alkyl group, an alkenyl group, an alkynyl group, or an aryl group.

摘要翻译： 具有下式的化合物：其中X是S，SO或SO 2; R 1，R 2和R 3中的一个为O，R 1，R 2和R 3中的一个独立地为相同或不同的CH 2或CR 13，其中R 13为烷基，烯基，炔基，三烷基甲硅烷基 或 - （CH 2）m OR 15，其中R 15是烷基或芳基，m是1至10的整数，R 5，R 6和R 7中的一个是O，而其中R 5，R 6和 R7独立地相同或不同，CH2或CR14，其中R14是烷基，烯基，炔基，三烷基甲硅烷基或 - （CH2）nOR16，其中R16是烷基或芳基 n为1〜10的整数， R4和R8独立地相同或不同，为氢，烷基，烯基，炔基，芳基，杂芳基，C1-C3烷氧基，芳氧基或 - （CH2）qOR17 其中R 17为烷基或芳基，q为1〜10的整数，条件是当R 1或R 3为O时，R 4不为C 1 -C 3烷氧基或芳氧基，且R 8不为 当R 5或R 7为O时，C 1 -C 3烷氧基或芳氧基; R 9，R 10，R 11和R 12独立地为相同或不同的H，烷基，烯基，炔基或芳基。