公开(公告)号：US20190022093A1

公开(公告)日：2019-01-24

申请号：US16139950

申请日：2018-09-24

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Peter Wipf ,  James K. Johnson ,  Erin M. Skoda ,  Joel B. Nelson ,  Zhou Wang ,  Serene Tai ,  Keita Takubo ,  John Milligan

IPC分类号： A61K31/504 ,  A61K31/4985 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/401 ,  A61K31/407 ,  A61K31/167 ,  A61K31/122 ,  A61K31/47 ,  A61K9/00 ,  A61P35/00

摘要： A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20-(Z)b-(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(═O), —S(═O)(═O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, cycloalkenediyl, substituted cycloalkenediyl, alkatrienyl, substituted alkatrienyl; X is —C(═O)—, —S(═O)(═O)—, or —N(H)C(═O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.

公开(公告)号：US11766433B2

公开(公告)日：2023-09-26

申请号：US17089519

申请日：2020-11-04

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Peter Wipf ,  James K. Johnson ,  Erin M. Skoda ,  Joel B. Nelson ,  Zhou Wang ,  Serene Tai ,  Keita Takubo ,  John Milligan

IPC分类号： A61K31/495 ,  A61K31/504 ,  A61K31/4985 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/401 ,  A61K31/407 ,  A61K31/122 ,  A61K31/47 ,  A61K9/00 ,  A61P35/00 ,  A61K31/167 ,  A61K31/4166 ,  A61K31/58

CPC分类号： A61K31/504 ,  A61K9/0053 ,  A61K31/122 ,  A61K31/167 ,  A61K31/401 ,  A61K31/407 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/497 ,  A61K31/4985 ,  A61P35/00 ,  A61K31/4166 ,  A61K31/58 ,  A61K2300/00

摘要： A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I:

R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23

wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(═O), —S(═O)(═O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, cycloalkenediyl, substituted cycloalkenediyl, alkatrienyl, substituted alkatrienyl; X is —C(═O)—, —S(═O)(═O)—, or —N(H)C(═O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.

公开(公告)号：US20210186963A1

公开(公告)日：2021-06-24

申请号：US17089519

申请日：2020-11-04

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Peter Wipf ,  James K. Johnson ,  Erin M. Skoda ,  Joel B. Nelson ,  Zhou Wang ,  Serene Tai ,  Keita Takubo ,  John Milligan

IPC分类号： A61K31/504 ,  A61K31/4985 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/401 ,  A61K31/407 ,  A61K31/122 ,  A61K31/47 ,  A61K9/00 ,  A61P35/00 ,  A61K31/167

摘要： A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(═O), S(═O)(═O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, cycloalkenediyl, substituted cycloalkenediyl, alkatrienyl, substituted alkatrienyl; X is —C(═O)—, —S(═O)(═O)—, or —N(H)C(═O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.

公开(公告)号：US10980806B2

公开(公告)日：2021-04-20

申请号：US16139950

申请日：2018-09-24

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Peter Wipf ,  James K. Johnson ,  Erin M. Skoda ,  Joel B. Nelson ,  Zhou Wang ,  Serene Tai ,  Keita Takubo ,  John Milligan

IPC分类号： A61P35/04 ,  A61K31/504 ,  A61K31/4985 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/401 ,  A61K31/407 ,  A61K31/122 ,  A61K31/47 ,  A61K9/00 ,  A61P35/00 ,  A61K31/167 ,  A61K31/4166 ,  A61K31/58

摘要： A compound, or a pharmaceutically acceptable salt or ester thereof, according to formula I: R20—(Z)b—(Y)c—(R21)a—(X)d—R22—R23 wherein R20 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; Z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; Y is S, O, S(═O), —S(═O)(═O)—, or NR10, wherein R10 is H or alkyl; R21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, cycloalkenediyl, substituted cycloalkenediyl, alkatrienyl, substituted alkatrienyl; X is —C(═O)—, —S(═O)(═O)—, or —N(H)C(═O)—; R22 includes at least one divalent amino radical; R23 is aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a thio-containing group, or a seleno-containing group; a, b, c, and d independently are 0 or 1.