公开(公告)号：US11247985B2

公开(公告)日：2022-02-15

申请号：US16748654

申请日：2020-01-21

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education ,  National Institutes of Health, A Component of the United States Department of Health and Human Services ,  The Regents of the University of California

发明人： Donna M. Huryn ,  Peter Wipf ,  Matthew G. LaPorte ,  Raffaele Colombo ,  Marina Kovaliov ,  Chaemin Lim ,  Celeste Natalie Alverez ,  Zhizhou Yue ,  Lalith Palitha Samankumara ,  Alexander Julian Chatterley ,  Yongzhao Yan ,  Mary Liang ,  Neal J. Green ,  Eric T. Baldwin ,  William J. Moore ,  Michelle Arkin ,  R. Jeffrey Neitz ,  Kean-Hooi Ang ,  Clifford Bryant ,  Stacie Bulfer

IPC分类号： C07D401/10 ,  A61P35/00 ,  C07D405/14 ,  C07D401/14 ,  A61P25/28 ,  C07D413/14 ,  C07D417/14

摘要： The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.

公开(公告)号：US20180319778A1

公开(公告)日：2018-11-08

申请号：US15769987

申请日：2016-10-20

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education ,  National Institute of Health, A Component of the U.S Department of Health and Human Services ,  The Regents of the University of California

发明人： Donna M. HURYN ,  Peter Wipf ,  Matthew G. LaPorte ,  Raffaele Colombo ,  Marina Kovaliov ,  Chaemin Lim ,  Celeste Natalie Alverez ,  Zhizhou Yue ,  Lalith Palitha Samankumara ,  Alexander Julian Chatterley ,  Yongzhao Yan ,  Mary Liang ,  Neal J. Green ,  Eric T. Baldwin ,  William J. Moore ,  Michelle Arkin ,  R. Jeffrey Neilz ,  Kean-Hooi Ang ,  Cliffford Bryant ,  Stacie Bulfer

IPC分类号： C07D405/14 ,  C07D401/14 ,  C07D401/10 ,  C07D413/14 ,  C07D417/14 ,  A61P25/28 ,  A61P35/00

CPC分类号： C07D405/14 ,  A61K31/404 ,  A61K31/454 ,  A61K31/496 ,  A61P25/28 ,  A61P35/00 ,  C07D401/10 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.

公开(公告)号：US20200157082A1

公开(公告)日：2020-05-21

申请号：US16748654

申请日：2020-01-21

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education ,  National Institutes of Health, A Component of the U.S. Department of Health and Human Services ,  The Regents of the University of California

发明人： Donna M. Huryn ,  Peter Wipf ,  Matthew G. LaPorte ,  Raffaele Colombo ,  Marina Kovaliov ,  Chaemin Lim ,  Celeste Natalie Alverez ,  Zhizhou Yue ,  Lalith Palitha Samankumara ,  Alexander Julian Chatterley ,  Yongzhao Yan ,  Mary Liang ,  Neal J. Green ,  Eric T. Baldwin ,  William J. Moore ,  Michelle Arkin ,  R. Jeffrey Neitz ,  Kean-Hooi Ang ,  Clifford Bryant ,  Stacie Bulfer

IPC分类号： C07D405/14 ,  C07D417/14 ,  C07D413/14 ,  A61P35/00 ,  A61P25/28 ,  C07D401/10 ,  C07D401/14

摘要： The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.

公开(公告)号：US20220112179A1

公开(公告)日：2022-04-14

申请号：US17556147

申请日：2021-12-20

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education ,  National Institutes of Health, A component of the United States Department of Health and Human Servi ,  The Regents of the University of California

发明人： Donna M. Huryn ,  Peter Wipf ,  Matthew G. LaPorte ,  Raffaele Colombo ,  Marina Kovaliov ,  Chaemin Lim ,  Celeste Natalie Alverez ,  Zhizhou Yue ,  Lalith Palitha Samankumara ,  Alexander Julian Chatterley ,  Yongzhao Yan ,  Mary Liang ,  Neal J. Green ,  Eric T. Baldwin ,  William J. Moore ,  Michelle Arkin ,  R. Jeffrey Neitz ,  Kean-Hooi Ang ,  Clifford Bryant ,  Stacie Bulfer

IPC分类号： C07D405/14 ,  A61P35/00 ,  C07D401/10 ,  C07D413/14 ,  C07D401/14 ,  C07D417/14 ,  A61P25/28

摘要： The present invention is directed to methods of inhibiting p97 and compounds and compositions useful in such methods. Diseases and conditions the can be treated with the compounds and compositions of the invention include, but are not limited to, cancer and neurodegenerative disorders susceptible to treatment by inhibition of p97.