公开(公告)号：US20240051931A1

公开(公告)日：2024-02-15

申请号：US18039941

申请日：2021-12-02

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Peter Wipf ,  Donna M. Huryn ,  Matthew G. LaPorte ,  Leila Terrab ,  Michael James Houghton ,  Andrea Topacio ,  Taber Sarah Maskrey ,  Tyler Kristufek ,  Uygar Sozer ,  Desirae Lynn Crocker ,  Sipak Joyasawal ,  Alyssa Thornton ,  Shikha Singh Chauhan ,  Mary Liang ,  Prema Iyer ,  Jagannath Panda

IPC分类号： C07D311/66 ,  C07D405/12 ,  C07D265/36 ,  C07D405/04

CPC分类号： C07D311/66 ,  C07D405/12 ,  C07D265/36 ,  C07D405/04

摘要： The present disclosure is directed to chromane compounds, chromane compounds demonstrating HDAC inhibition, and pharmaceutical compositions thereof. Additional embodiments include methods of using the chromane compounds. For example, the disclosure includes methods of inhibiting histone acetylation in a cell, comprising contacting the cell with a chromane compound of the disclosure. Additional embodiments include methods of treating a disease capable of treatment by inhibition of histone acetylation in a patient in need thereof, comprising administering a chromane compound of the disclosure.