公开(公告)号：US09708276B2

公开(公告)日：2017-07-18

申请号：US14351126

申请日：2012-10-10

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Zhou Wang ,  Joel Byron Nelson ,  Minh Mindy Bao Nguyen ,  John S. Lazo ,  Paul A. Johnston ,  Peter Wipf

IPC分类号： A61K31/407 ,  A61K31/496 ,  C07D261/08 ,  C07D295/16 ,  A61K31/495 ,  C07D401/04 ,  C07D235/02 ,  C07D403/04 ,  C07D409/04 ,  C07D413/04 ,  C07D241/04 ,  C07D417/04 ,  C07D261/04 ,  A61K31/4188 ,  A61K31/58 ,  A61K31/4965 ,  A61K45/06 ,  C07D487/04

CPC分类号： A61K31/496 ,  A61K31/407 ,  A61K31/4188 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/58 ,  A61K45/06 ,  C07D235/02 ,  C07D241/04 ,  C07D261/04 ,  C07D261/08 ,  C07D295/16 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/08 ,  C07D487/04 ,  A61K2300/00

摘要： A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: (a) a phenyl-substituted imidazole, or a pharmaceutically acceptable salt or ester thereof; or (b) a compound, or a pharmaceutically acceptable salt or ester thereof, having a formula I of: wherein R20 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; R21 is an alkanediyl or a substituted alkanediyl; a is 0 or 1; c is 0 or 1; X is C or S; R22 is a moiety that includes at least one divalent amino radical; and R23 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group.

公开(公告)号：US20170246164A1

公开(公告)日：2017-08-31

申请号：US15457782

申请日：2017-03-13

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Zhou Wang ,  Joel Byron Nelson ,  Minh Bao Nguyen ,  John S. Lazo ,  Paul A. Johnston ,  Peter Wipf

IPC分类号： A61K31/496 ,  A61K31/495 ,  A61K31/4188

CPC分类号： A61K31/496 ,  A61K31/407 ,  A61K31/4188 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/58 ,  A61K45/06 ,  C07D235/02 ,  C07D241/04 ,  C07D261/04 ,  C07D261/08 ,  C07D295/16 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/08 ,  C07D487/04 ,  A61K2300/00

摘要： A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: (a) a phenyl-substituted imidazole, or a pharmaceutically acceptable salt or ester thereof; or (b) a compound, or a pharmaceutically acceptable salt or ester thereof, having a formula I of: wherein R20 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; R21 is an alkanediyl or a substituted alkanediyl; a is 0 or 1; c is 0 or 1; X is C or S; R22 is a moiety that includes at least one divalent amino radical; and R23 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group.

公开(公告)号：US10004730B2

公开(公告)日：2018-06-26

申请号：US15457782

申请日：2017-03-13

申请人： University of Pittsburgh-Of the Commonwealth System of Higher Education

发明人： Zhou Wang ,  Joel Byron Nelson ,  Minh Bao Nguyen ,  John S. Lazo ,  Paul A. Johnston ,  Peter Wipf

IPC分类号： A61K31/69 ,  A61K31/66 ,  A61K31/497 ,  A61K31/4965 ,  A61K31/415 ,  A61K31/16 ,  A61K31/496 ,  A61K31/4188 ,  A61K31/495

CPC分类号： A61K31/496 ,  A61K31/407 ,  A61K31/4188 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/58 ,  A61K45/06 ,  C07D235/02 ,  C07D241/04 ,  C07D261/04 ,  C07D261/08 ,  C07D295/16 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/08 ,  C07D487/04 ,  A61K2300/00

摘要： A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: (a) a phenyl-substituted imidazole, or a pharmaceutically acceptable salt or ester thereof; or (b) a compound, or a pharmaceutically acceptable salt or ester thereof, having a formula I of:  wherein R20 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; R21 is an alkanediyl or a substituted alkanediyl; a is 0 or 1; c is 0 or 1; X is C or S; R22 is a moiety that includes at least one divalent amino radical; and R23 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group.

公开(公告)号：US09981974B2

公开(公告)日：2018-05-29

申请号：US15457774

申请日：2017-03-13

申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education

发明人： Zhou Wang ,  Joel Byron Nelson ,  Minh Bao Nguyen ,  John S. Lazo ,  Paul A. Johnston ,  Peter Wipf

IPC分类号： C07D487/04 ,  C07D471/08

CPC分类号： A61K31/496 ,  A61K31/407 ,  A61K31/4188 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/58 ,  A61K45/06 ,  C07D235/02 ,  C07D241/04 ,  C07D261/04 ,  C07D261/08 ,  C07D295/16 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/08 ,  C07D487/04 ,  A61K2300/00

摘要： A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: (a) a phenyl-substituted imidazole, or a pharmaceutically acceptable salt or ester thereof; or (b) a compound, or a pharmaceutically acceptable salt or ester thereof, having a formula I of: wherein R20 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; R21 is an alkanediyl or a substituted alkanediyl; a is 0 or 1; c is 0 or 1; X is C or S; R22 is a moiety that includes at least one divalent amino radical; and R23 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group.

公开(公告)号：US20210395266A1

公开(公告)日：2021-12-23

申请号：US17309260

申请日：2019-11-12

申请人： University of Virginia Patent Foundation ,  University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： John S. Lazo ,  Elizabeth Sharlow ,  Peter Wipf ,  Nikhil Tasker ,  Ettore Rastelli

IPC分类号： C07D495/04

摘要： The disclosure provides compounds that inhibit protein tyrosine phosphatase, such as protein tyrosine phosphatase 4A3 (PTP4A3). The disclosure also provides pharmaceutical compositions, uses, and methods of using the compounds, such as in the treatment of cancers. (I), wherein X is O or NH.

公开(公告)号：US20170247382A1

公开(公告)日：2017-08-31

申请号：US15457774

申请日：2017-03-13

申请人： University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： Zhou Wang ,  Joel Byron Nelson ,  Minh Bao Nguyen ,  John S. Lazo ,  Paul A. Johnston ,  Peter Wipf

IPC分类号： C07D487/04 ,  C07D471/08

CPC分类号： A61K31/496 ,  A61K31/407 ,  A61K31/4188 ,  A61K31/495 ,  A61K31/4965 ,  A61K31/58 ,  A61K45/06 ,  C07D235/02 ,  C07D241/04 ,  C07D261/04 ,  C07D261/08 ,  C07D295/16 ,  C07D401/04 ,  C07D403/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D471/08 ,  C07D487/04 ,  A61K2300/00

摘要： A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein the agent is selected from: (a) a phenyl-substituted imidazole, or a pharmaceutically acceptable salt or ester thereof; or (b) a compound, or a pharmaceutically acceptable salt or ester thereof, having a formula I of: wherein R20 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; R21 is an alkanediyl or a substituted alkanediyl; a is 0 or 1; c is 0 or 1; X is C or S; R22 is a moiety that includes at least one divalent amino radical; and R23 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group.