公开(公告)号：US20210155936A1

公开(公告)日：2021-05-27

申请号：US17159881

申请日：2021-01-27

Applicant: University of Southampton

Inventor： Igor VORECHOVSKY ,  Jana KRALOVICOVA

IPC: C12N15/113 ,  C12Q1/6883 ,  C12Q1/6886

Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.

公开(公告)号：US20230416756A1

公开(公告)日：2023-12-28

申请号：US18299509

申请日：2023-04-12

Applicant: University of Southampton

Inventor： Igor VORECHOVSKY ,  Jana KRALOVICOVA

IPC: C12N15/113 ,  C12Q1/6883 ,  C12Q1/6886

CPC classification number: C12N15/1137 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12N15/113 ,  C12N2320/33 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12N2310/14 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3519 ,  C12N2320/34

Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.