公开(公告)号：US10538764B2

公开(公告)日：2020-01-21

申请号：US15619984

申请日：2017-06-12

Applicant: University of Southampton

Inventor： Igor Vorechovsky ,  Jana Kralovicova

IPC: C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C12Q1/6883 ,  C12N15/11

Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.

公开(公告)号：US20240309377A1

公开(公告)日：2024-09-19

申请号：US18540453

申请日：2023-12-14

Applicant: University of Southampton

Inventor： Igor Vorechovsky ,  Jana Kralovicova

IPC: C12N15/113 ,  C12N15/11 ,  C12Q1/6883

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12Q1/6883 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/346 ,  C12N2310/3521 ,  C12N2320/33

Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.

公开(公告)号：US20190264211A1

公开(公告)日：2019-08-29

申请号：US16213535

申请日：2018-12-07

Applicant: University of Southampton

Inventor： Igor Vorechovsky ,  Jana Kralovicova

IPC: C12N15/113 ,  C12Q1/6883 ,  C12Q1/6886

Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.

公开(公告)号：US20170101641A1

公开(公告)日：2017-04-13

申请号：US15288415

申请日：2016-10-07

Applicant: University of Southampton

Inventor： Igor Vorechovsky ,  Jana Kralovicova

IPC: C12N15/113

CPC classification number: C12N15/1137 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3519 ,  C12N2320/33 ,  C12N2320/34 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12N2310/3521

Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.

公开(公告)号：US20160244762A1

公开(公告)日：2016-08-25

申请号：US15148303

申请日：2016-05-06

Applicant: University of Southampton

Inventor： Igor Vorechovsky ,  Jana Kralovicova

IPC: C12N15/113

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/346 ,  C12N2310/3521 ,  C12N2320/33 ,  C12Q1/6883

Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.

Abstract translation: 本文公开了用于诱导加工部分处理的mRNA转录物以除去保留的内含子以产生编码蛋白质的全长功能形式的完全加工的mRNA转录物的方法，组合物，聚核酸聚合物，测定和试剂盒。 本文还描述了用于治疗疾病或病症的方法和组合物，其特征在于蛋白质的全长功能形式的产生受损或用于治疗特征在于受试者中拼接缺陷的疾病或病症。

公开(公告)号：US11891605B2

公开(公告)日：2024-02-06

申请号：US17846794

申请日：2022-06-22

Applicant: University of Southampton

Inventor： Igor Vorechovsky ,  Jana Kralovicova

IPC: C07H21/02 ,  C12N15/113 ,  C12Q1/6883 ,  C12N15/11

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12Q1/6883 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/346 ,  C12N2310/3521 ,  C12N2320/33 ,  C12N2310/321 ,  C12N2310/3521

Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.

公开(公告)号：US20230183693A1

公开(公告)日：2023-06-15

申请号：US17846794

申请日：2022-06-22

Applicant: University of Southampton

Inventor： Igor Vorechovsky ,  Jana Kralovicova

IPC: C12N15/113 ,  C12Q1/6883 ,  C12N15/11

CPC classification number: C12N15/113 ,  C12Q1/6883 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/346 ,  C12N2320/33 ,  C12N2310/113 ,  C12N2310/321 ,  C12N2310/3521

Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.

公开(公告)号：US20180002694A1

公开(公告)日：2018-01-04

申请号：US15619984

申请日：2017-06-12

Applicant: University of Southampton

Inventor： Igor Vorechovsky ,  Jana Kralovicova

IPC: C12N15/113 ,  C12N15/11 ,  C12Q1/68

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/346 ,  C12N2310/3521 ,  C12N2320/33 ,  C12Q1/6883

Abstract: Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.

公开(公告)号：US11702660B2

公开(公告)日：2023-07-18

申请号：US17159881

申请日：2021-01-27

Applicant: University of Southampton

Inventor： Igor Vorechovsky ,  Jana Kralovicova

IPC: C12N15/113 ,  C12Q1/6883 ,  C12Q1/6886

CPC classification number: C12N15/1137 ,  C12N15/113 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3519 ,  C12N2320/33 ,  C12N2320/34 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12N2310/321 ,  C12N2310/3521

Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.

公开(公告)号：US10941405B2

公开(公告)日：2021-03-09

申请号：US16213535

申请日：2018-12-07

Applicant: University of Southampton

Inventor： Igor Vorechovsky ,  Jana Kralovicova

IPC: C12N15/113 ,  C12Q1/6883 ,  C12Q1/6886

Abstract: Disclosed herein include compositions and methods of modulating protein expression that utilizes an activator or a repressor of a non-sense mediated RNA decay switch exon (NSE). In some embodiments, also included herein are compositions and methods of modulating protein expression that uses an agent that targets a transposed element.