公开(公告)号：US11786521B2

公开(公告)日：2023-10-17

申请号：US17503760

申请日：2021-10-18

Applicant: University of Southern California

Inventor： Thomas Chen

IPC: A61K31/495 ,  C07D231/12 ,  A61K31/4188 ,  A61K47/54 ,  C07B59/00 ,  A61K31/4015 ,  A61K9/00 ,  A61K31/045 ,  A61K31/415 ,  C07D207/26 ,  C07C33/14 ,  C07D487/04 ,  A61K45/06 ,  A61N5/10 ,  A61K31/635 ,  A61K47/55 ,  A61K31/366

CPC classification number: A61K31/495 ,  A61K9/0043 ,  A61K31/045 ,  A61K31/366 ,  A61K31/4015 ,  A61K31/415 ,  A61K31/4188 ,  A61K31/635 ,  A61K45/06 ,  A61K47/54 ,  A61K47/542 ,  A61K47/543 ,  A61K47/55 ,  A61N5/10 ,  C07B59/00 ,  C07C33/14 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04 ,  C07B2200/05 ,  C07C2601/16

Abstract: The present methods treat neurofibromatosis by a administering to a subject perillyl alcohol or iso-perillyl alcohol. The present methods also treat neurofibromatosis by administering to a subject a carbamate of perillyl alcohol, or a carbamate of iso-perillyl alcohol. The perillyl alcohol carbamate may comprise perillyl alcohol conjugated with rolipram or temozolomide.