-
公开(公告)号:US20230158209A1
公开(公告)日:2023-05-25
申请号:US18057125
申请日:2022-11-18
Applicant: University of Southern California , Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California
Inventor: Yang Chai , Mengfei Yu
CPC classification number: A61L27/3834 , A61L27/24 , A61L27/26 , A61L27/54 , A61L27/58 , A61L27/222 , A61L27/227 , A61L27/3633 , A61L2300/412
Abstract: Disclosed herein are compositions of biodegradable scaffolds combined with mesenchymal stem cells and methods of use thereof for the regeneration of cranial sutures and treatment of craniosynostosis, which can help reverse increased intracranial pressure and skull and neurocognitive abnormalities.
-
公开(公告)号:US10646518B2
公开(公告)日:2020-05-12
申请号:US15500726
申请日:2015-08-07
Applicant: Alfred E. Mann Institute for Biomedical Engineering at the University of Southern California , University of Southern California
Inventor: Songtao Shi , Dawei Liu , Cunye Qu
IPC: A61K35/28 , C12N5/0775 , A61K35/12 , A61K9/00
Abstract: This disclosure relates to apoptotic bodies. The disclosure particularly relates to a composition comprising the apoptotic bodies. The disclosure further relates to preparation of apoptotic bodies from stem cells. The disclosure also relates to medical treatments comprising the use of the composition comprising the apoptotic bodies. The apoptotic bodies may comprise apoptotic stem cells. The apoptosis of a cell may be induced by a starvation method, an ultra-violet irradiation method, a thermal stress method, a staurosporine method, or a combination thereof.
-
公开(公告)号:US12186352B2
公开(公告)日:2025-01-07
申请号:US17982067
申请日:2022-11-07
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor: Valter D. Longo , Min Wei , Priya Rangan
IPC: A61K35/747 , A23L3/44 , A23L33/135 , A61K9/16 , A61K9/48 , A61K35/00 , A61K35/745 , A61K45/06
Abstract: A method for treating autoimmune and/or inflammatory disease includes a step of identifying a subject exhibiting symptoms of autoimmune and/or inflammatory disease administering a fasting mimicking diet. A probiotic composition for gastrointestinal autoimmune and/or inflammatory disease Bacteroides acidifaciens, Bifidobacterium choerinum, and combinations thereof is also provided.
-
公开(公告)号:US20240412338A1
公开(公告)日:2024-12-12
申请号:US18694889
申请日:2022-09-22
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor: Hsiao-Ju CHIANG , Eun Sang KOO , Scott E. FRASER , Francesco CUTRALE
Abstract: Hybrid unmixing technique (HyU) of this disclosure may provide enhanced imaging of multiplexed fluorescence labels, enabling longitudinal imaging of multiple fluorescent signals with reduced illumination intensities. This disclosure generally relates to imaging systems. This disclosure relates to hyperspectral imaging systems. This disclosure further relates to hyperspectral imaging systems that generate an unmixed color image of a target. This disclosure further relates to a hyperspectral imaging system that is configured to use a hybrid unmixing technique to provide enhanced imaging of a target. This disclosure further relates to a hyperspectral imaging system that is configured to use a hybrid unmixing technique to provide enhanced imaging of multiplexed fluorescence labels, enabling longitudinal imaging of multiple fluorescent signals with reduced illumination intensities. This disclosure further relates to hyperspectral imaging systems that are used in diagnosing a health condition.
-
公开(公告)号:US20240392011A1
公开(公告)日:2024-11-28
申请号:US18620185
申请日:2024-03-28
Applicant: University of Southern California
Inventor: Alan L. Epstein , Peisheng Hu
IPC: C07K16/28 , A61K39/00 , A61K39/395 , A61P35/00 , C07K14/705 , C07K14/725 , C12N5/0783 , G01N33/569 , G01N33/574
Abstract: CAR cells targeting and antibodies human HLA-G are described as a new method of cancer treatment. It is proposed that HLA-G CAR cells are safe and effective in patients and can be used to treat human tumors expressing the HLA-G.
-
公开(公告)号:US20240324264A1
公开(公告)日:2024-09-26
申请号:US18669611
申请日:2024-05-21
Inventor: Mark E. Thompson , Abegail Tadle , Muazzam Idris , Karim El Roz , Daniel Sylvinson Muthiah Ravinson , Stephen R. Forrest , Chan Ho Soh
IPC: H10K50/11 , C07D233/58 , C07D401/10 , C09K11/06 , H10K50/125 , H10K85/30 , H10K85/60 , H10K101/00 , H10K101/10 , H10K101/30
CPC classification number: H10K50/11 , C07D233/58 , C07D401/10 , C09K11/06 , H10K50/125 , H10K85/322 , H10K85/654 , H10K85/6572 , C09K2211/1018 , H10K2101/10 , H10K2101/27 , H10K2101/30 , H10K2101/90
Abstract: A hybrid emissive layer and OLED incorporating the same are provided. The hybrid emissive layer includes a first material having a triplet state energy level T1H and a singlet state energy level S1H, & second material having a triplet state energy level T1F and a singlet state energy level S1F; and a third material having a triplet state energy level T1P and a single state energy level S1P, where T1F≥T1H; S1F≤S1H; and T1P
-
公开(公告)号:US20240323726A1
公开(公告)日:2024-09-26
申请号:US18124801
申请日:2023-03-22
Applicant: KDDI Research, Inc. , University of Southern California
Inventor: Masaaki ITO , Issei KANNO , Kosuke YAMAZAKI , Andreas F. MOLISCH
IPC: H04W24/10
CPC classification number: H04W24/10
Abstract: A method performed by a processing apparatus of a cell-free communication system that includes a plurality of access points (APs) is provided. The method includes: transmitting, to a wireless device via a master AP among one or more APs included in a cluster associated with the wireless device, measurement information for the wireless device to determine a measurement target AP for which the wireless device measures a channel state; and receiving, as a response to the measurement information, channel state information indicating the channel state to the measurement target AP, via the master AP.
-
公开(公告)号:US12098353B2
公开(公告)日:2024-09-24
申请号:US18124923
申请日:2023-03-22
Applicant: University of Southern California
Inventor: Megan McCain , Joycelyn Yip , Ching-Ling Lien , Michael Harrison
CPC classification number: C12M23/16 , A01N1/0247 , B01L3/502715 , C12M23/22 , C12M23/24 , B01L2200/0684 , B01L2300/087 , B01L2300/0877 , B01L2300/12
Abstract: Zebrafish are a powerful model for investigating cardiac repair due to their unique regenerative abilities, scalability, and compatibility with many genetic tools. However, characterizing the regeneration process in live adult zebrafish hearts has proved challenging because adult fish are opaque and explanted hearts in conventional culture conditions experience rapid declines in morphology and physiology. To overcome these limitations, we fabricated a fluidic device for culturing explanted adult zebrafish hearts with constant media perfusion that is also compatible with live imaging. Unlike hearts cultured in dishes for one week, the morphology and calcium activity of hearts cultured in the device for one week were largely similar to freshly explanted hearts. We also cultured injured hearts in the device and used live imaging techniques to continuously record the revascularization process over several days, demonstrating how our device enables unprecedented visual access to the multi-day process of adult zebrafish heart regeneration.
-
公开(公告)号:US12094899B2
公开(公告)日:2024-09-17
申请号:US17333847
申请日:2021-05-28
Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
Inventor: Wei Wu , Tse-Hsien Ou , Yunxiang Wang , Hao Yang
IPC: H01L27/146
CPC classification number: H01L27/1462 , H01L27/14685
Abstract: A semiconductor-based sensor with enhanced light absorption, and in particular, enhanced infrared light absorption includes a semiconductor light sensor element and a patterned spatially inhomogeneous dielectric layer disposed over the semiconductor light sensor element. Characteristically, spatial inhomogeneity of the patterned spatially inhomogeneous dielectric layer is optimized to provide a maximized electric field in the semiconductor light sensor element such light absorption is enhanced.
-
公开(公告)号:US20240298689A1
公开(公告)日:2024-09-12
申请号:US18657307
申请日:2024-05-07
Applicant: University of Southern California
Inventor: Valter D. LONGO , Chia-Wei CHENG
IPC: A23L33/00
CPC classification number: A23L33/30 , A23L33/40 , A23V2002/00
Abstract: A method of alleviating symptoms of, or treating, pancreatic beta-cell damage in a subject includes a step of identifying a subject having pancreatic beta-cell damage. Multiple cycles of a diet protocol are administered to the subject. The diet protocol includes administering of a fasting mimicking diet and a re-feeding diet where the fasting mimicking diet is provided for a first time period and the re-feeding diet is provided for a second time period.
-
-
-
-
-
-
-
-
-