公开(公告)号：US20240342310A1

公开(公告)日：2024-10-17

申请号：US18625283

申请日：2024-04-03

Applicant: University of Virginia Patent Foundation ,  Sun Yat Sen Memorial Hospital, Sun Yat Sen University

Inventor： Hui Li ,  Qiong Wang ,  Hai Huang

IPC: A61K48/00 ,  A61K38/00 ,  A61P35/00 ,  C07K14/47

CPC classification number: A61K48/005 ,  A61P35/00 ,  C07K14/47 ,  A61K38/00 ,  C07K2319/02

Abstract: Disclosed herein are peptides and peptidomimetics that inhibit the progression of prostate cancer by up-regulating FLRT3. Also disclosed are methods for treating an FLRT3-attenuated cancer in a subject that involve administering to the subject the disclosed polypeptide or peptidomimetic or a polynucleotide encoding the disclosed peptide.

公开(公告)号：US11957682B2

公开(公告)日：2024-04-16

申请号：US17809145

申请日：2022-06-27

Applicant: University of Virginia Patent Foundation

Inventor： Hui Li ,  Zhongqiu Xie

IPC: A61K31/506 ,  A61K31/40 ,  A61K31/454 ,  A61K45/06 ,  A61P35/04

CPC classification number: A61K31/506 ,  A61K31/40 ,  A61K31/454 ,  A61P35/04 ,  A61K45/06

Abstract: In one aspect, the disclosure relates to compounds useful to regulate, limit, or inhibit the expression of AVIL (advillin), methods of making same, pharmaceutical compositions comprising same, and methods of treating disorders associated with AVIL dysregulation using same. In aspects, the disclosed compounds, compositions and methods are useful for treating disorders or diseases in which the regulation, limitation, or inhibition of the expression of AVIL can be clinically useful, such as, for example, the treatment of cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US11369608B2

公开(公告)日：2022-06-28

申请号：US16759210

申请日：2018-10-26

Applicant: University of Virginia Patent Foundation

Inventor： Hui Li ,  Zhongqiu Xie

IPC: A61K31/506 ,  A61P35/04 ,  A61K31/40 ,  A61K31/454 ,  A61K45/06

Abstract: In one aspect, the disclosure relates to compounds useful to regulate, limit, or inhibit the expression of AVIL (advillin), methods of making same, pharmaceutical compositions comprising same, and methods of treating disorders associated with AVIL dys-regulation using same. In aspects, the disclosed compounds, compositions and methods are useful for treating disorders or diseases in which the regulation, limitation, or inhibition of the expression of AVIL can be clinically useful, such as, for example, the treatment of cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20200316063A1

公开(公告)日：2020-10-08

申请号：US16759210

申请日：2018-10-26

Applicant: University of Virginia Patent Foundation

Inventor： Hui Li ,  Zhongqiu Xie

IPC: A61K31/506 ,  A61K31/454 ,  A61K31/40 ,  A61P35/04

Abstract: In one aspect, the disclosure relates to compounds useful to regulate, limit, or inhibit the expression of AVIL (advillin), methods of making same, pharmaceutical compositions comprising same, and methods of treating disorders associated with AVIL dys-regulation using same. In aspects, the disclosed compounds, compositions and methods are useful for treating disorders or diseases in which the regulation, limitation, or inhibition of the expression of AVIL can be clinically useful, such as, for example, the treatment of cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20230018590A1

公开(公告)日：2023-01-19

申请号：US17809145

申请日：2022-06-27

Applicant: University of Virginia Patent Foundation

Inventor： Hui Li ,  Zhongqiu Xie

IPC: A61K31/506 ,  A61P35/04 ,  A61K31/40 ,  A61K31/454

Abstract: In one aspect, the disclosure relates to compounds useful to regulate, limit, or inhibit the expression of AVIL (advillin), methods of making same, pharmaceutical compositions comprising same, and methods of treating disorders associated with AVIL dysregulation using same. In aspects, the disclosed compounds, compositions and methods are useful for treating disorders or diseases in which the regulation, limitation, or inhibition of the expression of AVIL can be clinically useful, such as, for example, the treatment of cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US20220213055A1

公开(公告)日：2022-07-07

申请号：US17607577

申请日：2020-05-02

Applicant: University of Virginia Patent Foundation

Inventor： Hui Li ,  Zhongqiu Xie ,  Pawel Lukasz Janczyk ,  Michael Kenneth Hilinski ,  Philip Lee Hahn ,  Johnathon Daniel Dooley

IPC: C07D401/04 ,  C07D409/06 ,  A61K31/44 ,  A61K31/444 ,  A61K31/506 ,  A61K31/53 ,  A61K31/497 ,  A61K45/06

Abstract: In one aspect, the disclosure relates to compounds useful to regulate, limit, or inhibit the expression of AVIL (advillin), methods of making same, pharmaceutical compositions comprising same, and methods of treating disorders associated with AVIL dysregulation using same. In aspects, the disclosed compounds, compositions and methods are useful for treating disorders or diseases in which the regulation, limitation, or inhibition of the expression of AVIL can be clinically useful, such as, for example, the treatment of cancer. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.