公开(公告)号：US20220373627A1

公开(公告)日：2022-11-24

申请号：US17732181

申请日：2022-04-28

Applicant: University of Virginia Patent Foundation

Inventor： Zhixing Wang ,  Steven P. Allen ,  Xue Feng ,  John P. Mugler, III ,  Craig H. Meyer

IPC: G01R33/48 ,  G01R33/561 ,  G01R33/56 ,  G01R33/54 ,  G01R33/565

Abstract: Methods, computing devices, and magnetic resonance imaging systems that improve image quality in turbo spiral echo (TSE) imaging are disclosed. With this technology, a TSE pulse sequence is generated that includes a series of radio frequency (RF) refocusing pulses to produce a corresponding series of nuclear magnetic resonance (NMR) spin echo signals. A gradient waveform including a plurality of segments is generated. The plurality of segments collectively comprise a spiral ring retraced in-out trajectory. During an interval adjacent to each of the series of RF refocusing pulses, a first gradient pulse is generated according to the gradient waveform. The first gradient pulses encode the NMR spin echo signals. An image is then constructed from digitized samples of the NMR spin echo signals obtained based at least in part on the encoding.

公开(公告)号：US20240353514A1

公开(公告)日：2024-10-24

申请号：US18641158

申请日：2024-04-19

Applicant: University of Virginia Patent Foundation

Inventor： Craig H. Meyer ,  John P. Mugler, III ,  Grady Wilson Miller, IV ,  Sheng Chen ,  Helen L. Sporkin ,  Steven P. Allen ,  Zhixing Wang

IPC: G01R33/48 ,  G01R33/50

CPC classification number: G01R33/4814 ,  G01R33/4804 ,  G01R33/4816 ,  G01R33/50

Abstract: Described herein are systems, methods, and computer-readable medium for magnetic resonance (MR) based thermometry. A method for magnetic resonance based thermometry includes: acquiring, by a variable flip-angle T1 mapping sequence, MR data in an area of interest of a subject that is heated by the application of focused ultrasound (FUS) to the brain of the subject, where the MR data includes T1 values over time, and where the acquisition of the MR data includes applying an accelerated three-dimensional ultra-short spiral acquisition sequence with a nonselective excitation pulse; tracking changes in proton resonance frequency and determining, based at least in part on a mathematical relationship established by T1 mapping thermometry, a temperature change in the area of interest over time, and where the temperature change is caused at least in part by a change in the applied FUS.

公开(公告)号：US11921179B2

公开(公告)日：2024-03-05

申请号：US17732181

申请日：2022-04-28

Applicant: University of Virginia Patent Foundation

Inventor： Zhixing Wang ,  Steven P. Allen ,  Xue Feng ,  John P. Mugler, III ,  Craig H. Meyer

IPC: G01R33/48 ,  G01R33/54 ,  G01R33/56 ,  G01R33/561 ,  G01R33/565

CPC classification number: G01R33/482 ,  G01R33/543 ,  G01R33/5608 ,  G01R33/5617 ,  G01R33/56509

Abstract: Methods, computing devices, and magnetic resonance imaging systems that improve image quality in turbo spiral echo (TSE) imaging are disclosed. With this technology, a TSE pulse sequence is generated that includes a series of radio frequency (RF) refocusing pulses to produce a corresponding series of nuclear magnetic resonance (NMR) spin echo signals. A gradient waveform including a plurality of segments is generated. The plurality of segments collectively comprise a spiral ring retraced in-out trajectory. During an interval adjacent to each of the series of RF refocusing pulses, a first gradient pulse is generated according to the gradient waveform. The first gradient pulses encode the NMR spin echo signals. An image is then constructed from digitized samples of the NMR spin echo signals obtained based at least in part on the encoding.

公开(公告)号：US11644520B2

公开(公告)日：2023-05-09

申请号：US17144319

申请日：2021-01-08

Applicant: University of Virginia Patent Foundation

Inventor： Yekaterina K. Gilbo ,  Helen L. Sporkin ,  Samuel W. Fielden ,  John P. Mugler, III ,  Grady W. Miller, IV ,  Steven P. Allen ,  Craig H. Meyer

IPC: G01R33/48 ,  G01R33/561 ,  G01R33/38 ,  G01R33/50

CPC classification number: G01R33/4814 ,  G01R33/3804 ,  G01R33/4816 ,  G01R33/4818 ,  G01R33/50 ,  G01R33/561

Abstract: Described herein are systems, methods, and computer-readable medium for magnetic resonance (MR) based thermometry. In one aspect, in accordance with one embodiment, a method for magnetic resonance based thermometry includes: acquiring, by a variable flip-angle T1 mapping sequence, MR data in an area of interest of a subject that is heated by the application of focused ultrasound (FUS) to the brain of the subject, where the MR data includes T1 values over time, and where the acquisition of the MR data includes applying an accelerated three-dimensional ultra-short spiral acquisition sequence with a nonselective excitation pulse; and determining, based at least in part on a mathematical relationship established by T1 mapping thermometry, a temperature change in the area of interest over time, and where the temperature change is caused at least in part by a change in the applied FUS.

公开(公告)号：US20210208225A1

公开(公告)日：2021-07-08

申请号：US17144319

申请日：2021-01-08

Applicant: University of Virginia Patent Foundation

Inventor： Yekaterina K. Gilbo ,  Helen L. Sporkin ,  Samuel W. Fielden ,  John P. Mugler, III ,  Grady W. Miller, IV ,  Steven P. Allen ,  Craig H. Meyer

IPC: G01R33/48 ,  G01R33/50 ,  G01R33/38 ,  G01R33/561

Abstract: Described herein are systems, methods, and computer-readable medium for magnetic resonance (MR) based thermometry. In one aspect, in accordance with one embodiment, a method for magnetic resonance based thermometry includes: acquiring, by a variable flip-angle T1 mapping sequence, MR data in an area of interest of a subject that is heated by the application of focused ultrasound (FUS) to the brain of the subject, where the MR data includes T1 values over time, and where the acquisition of the MR data includes applying an accelerated three-dimensional ultra-short spiral acquisition sequence with a nonselective excitation pulse; and determining, based at least in part on a mathematical relationship established by T1 mapping thermometry, a temperature change in the area of interest over time, and where the temperature change is caused at least in part by a change in the applied FUS.