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公开(公告)号：US20170307705A1
公开(公告)日：2017-10-26
申请号：US15493842
申请日：2017-04-21
Inventor： John P. Mugler, III , Samuel W. Fielden , G. Wilson Miller, IV , Craig H. Meyer , Talissa A. Altes , Alto Stemmer , Josef Pfeuffer , Berthold Kiefer
Abstract: Some aspects of the present disclosure relate to ultrashort-echo-time (UTE) imaging. In one embodiment, a method includes acquiring UTE imaging data associated with an area of interest of a subject. The acquiring comprises applying an imaging pulse sequence with a three-dimensional (3D) spiral acquisition and a nonselective excitation pulse. The method also includes reconstructing at least one image of the area of interest from the acquired UTE imaging data.
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2.发明授权Systems and methods for accelerated arterial spin labeling using compressed sensing 有权使用压缩感应加速动脉自旋标记的系统和方法公开(公告)号：US09589345B2
公开(公告)日：2017-03-07
申请号：US14870803
申请日：2015-09-30
Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Inventor： Li Zhao , Xiao Chen , Samuel W. Fielden , Frederick H. Epstein , John P. Mugler, III , Manal Nicolas-Jilwan , Max Wintermark , Craig H. Meyer
IPC: G06K9/00 , G06T7/00 , G01R33/563 , G01R33/48 , G06K9/62 , G06T11/00 , A61B5/05 , G01R33/561
CPC classification number: G06T7/0012 , G01R33/4824 , G01R33/5611 , G01R33/56366 , G06K9/6232 , G06T11/005 , G06T2207/10088 , G06T2207/30104 , G06T2211/412 , G06T2211/424
Abstract: Systems and methods for accelerated arterial spin labeling (ASL) using compressed sensing are disclosed. In one aspect, in accordance with one example embodiment, a method includes acquiring magnetic resonance data associated with an area of interest of a subject, wherein the area of interest corresponds to one or more physiological activities of the subject. The method also includes performing image reconstruction using temporally constrained compressed sensing reconstruction on at least a portion of the acquired magnetic resonance data, wherein acquiring the magnetic resonance data includes receiving data associated with ASL of the area of interest of the subject.
Abstract translation: 公开了使用压缩感测加速动脉自旋标记（ASL）的系统和方法。 在一个方面，根据一个示例性实施例，一种方法包括获取与受试者的感兴趣区域相关联的磁共振数据，其中感兴趣区域对应于受试者的一个或多个生理活动。 该方法还包括在所获取的磁共振数据的至少一部分上使用时间上受限的压缩感测重构来执行图像重建，其中获取磁共振数据包括接收与被摄体的感兴趣区域的ASL相关联的数据。
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公开(公告)号：US11644520B2
公开(公告)日：2023-05-09
申请号：US17144319
申请日：2021-01-08
Applicant: University of Virginia Patent Foundation
Inventor： Yekaterina K. Gilbo , Helen L. Sporkin , Samuel W. Fielden , John P. Mugler, III , Grady W. Miller, IV , Steven P. Allen , Craig H. Meyer
IPC: G01R33/48 , G01R33/561 , G01R33/38 , G01R33/50
CPC classification number: G01R33/4814 , G01R33/3804 , G01R33/4816 , G01R33/4818 , G01R33/50 , G01R33/561
Abstract: Described herein are systems, methods, and computer-readable medium for magnetic resonance (MR) based thermometry. In one aspect, in accordance with one embodiment, a method for magnetic resonance based thermometry includes: acquiring, by a variable flip-angle T1 mapping sequence, MR data in an area of interest of a subject that is heated by the application of focused ultrasound (FUS) to the brain of the subject, where the MR data includes T1 values over time, and where the acquisition of the MR data includes applying an accelerated three-dimensional ultra-short spiral acquisition sequence with a nonselective excitation pulse; and determining, based at least in part on a mathematical relationship established by T1 mapping thermometry, a temperature change in the area of interest over time, and where the temperature change is caused at least in part by a change in the applied FUS.
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公开(公告)号：US20210208225A1
公开(公告)日：2021-07-08
申请号：US17144319
申请日：2021-01-08
Applicant: University of Virginia Patent Foundation
Inventor： Yekaterina K. Gilbo , Helen L. Sporkin , Samuel W. Fielden , John P. Mugler, III , Grady W. Miller, IV , Steven P. Allen , Craig H. Meyer
IPC: G01R33/48 , G01R33/50 , G01R33/38 , G01R33/561
Abstract: Described herein are systems, methods, and computer-readable medium for magnetic resonance (MR) based thermometry. In one aspect, in accordance with one embodiment, a method for magnetic resonance based thermometry includes: acquiring, by a variable flip-angle T1 mapping sequence, MR data in an area of interest of a subject that is heated by the application of focused ultrasound (FUS) to the brain of the subject, where the MR data includes T1 values over time, and where the acquisition of the MR data includes applying an accelerated three-dimensional ultra-short spiral acquisition sequence with a nonselective excitation pulse; and determining, based at least in part on a mathematical relationship established by T1 mapping thermometry, a temperature change in the area of interest over time, and where the temperature change is caused at least in part by a change in the applied FUS.
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公开(公告)号：US10718837B2
公开(公告)日：2020-07-21
申请号：US15493842
申请日：2017-04-21
Inventor： John P. Mugler, III , Samuel W. Fielden , G. Wilson Miller, IV , Craig H. Meyer , Talissa A. Altes , Alto Stemmer , Josef Pfeuffer , Berthold Kiefer
Abstract: Some aspects of the present disclosure relate to ultrashort-echo-time (UTE) imaging. In one embodiment, a method includes acquiring UTE imaging data associated with an area of interest of a subject. The acquiring comprises applying an imaging pulse sequence with a three-dimensional (3D) spiral acquisition and a nonselective excitation pulse. The method also includes reconstructing at least one image of the area of interest from the acquired UTE imaging data.
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Patent Agency Ranking
公开(公告)号：US10557908B2
公开(公告)日：2020-02-11
申请号：US15947443
申请日：2018-04-06
Inventor： Craig H. Meyer , John P. Mugler, III , Samuel W. Fielden , Gudrun Ruyters , Berthold Kiefer , Josef Pfeuffer
IPC: G01R33/561 , G01R33/563 , G01R33/48 , G01R33/565
Abstract: In some aspects, the disclosed technology relates to magnetic field monitoring of spiral echo train imaging. In one embodiment, a method for spiral echo train imaging of an area of interest of a subject includes measuring k-space values and field dynamics corresponding to each echo of a spiral echo pulse train, using a dynamic field camera and a magnetic resonance imaging (MRI) system. The dynamic field camera is configured to measure characteristics of fields generated by the MRI system; the characteristics include at least one imperfection associated with the MRI system. The spiral echo pulse train corresponds to a spiral trajectory scan from the MRI system that obtains magnetic resonance imaging data using a pulse sequence which applies spiral gradients in-plane with through-plane phase encoding. The method also includes generating, based on the characteristics of the fields measured by the dynamic field camera and based on the obtained magnetic resonance imaging data, a model of the k-space trajectory corresponding to each echo of the spiral echo pulse train; and, based on the generated model of the k-space trajectory, reconstructing images that correspond to the area of interest and that are compensated for the at least one imperfection associated with the MRI system.
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公开(公告)号：US09651645B2
公开(公告)日：2017-05-16
申请号：US15078790
申请日：2016-03-23
Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Inventor： Samuel W. Fielden , Craig H. Meyer , Xue Feng
IPC: G01V3/00 , G01R33/565 , G01R33/48
CPC classification number: G01R33/565 , G01R33/4824
Abstract: Systems, methods of reducing off-resonance blurring in acquired magnetic resonance imaging data. The method includes acquiring a first set of spiral interleaf data for each of one or more spiral-in/out interleaves by performing a first sampling each of one or more locations in k-space along a first redundant spiral-in/out trajectory, and acquiring a second set of spiral interleaf data for each of the one or more spiral-in/out interleaves by performing a second sampling of each of the one or more locations in the k-space along a second redundant spiral-in/out trajectory, wherein the second redundant spiral-in/out trajectory corresponds to a time-reversed trajectory of the first redundant spiral-in/out trajectory. The method may yet further include combining the first set of spiral interleaf data and the second set of spiral interleaf data with an averaging operation such as to reduce artifacts.
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8.发明申请公开(公告)号：US20160202335A1
公开(公告)日：2016-07-14
申请号：US15078790
申请日：2016-03-23
Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
Inventor： Samuel W. Fielden , Craig H. Meyer , Xue Feng
IPC: G01R33/48 , G01R33/565
CPC classification number: G01R33/565 , G01R33/4824
Abstract: Systems, methods of reducing off-resonance blurring in acquired magnetic resonance imaging data. The method includes acquiring a first set of spiral interleaf data for each of one or more spiral-in/out interleaves by performing a first sampling each of one or more locations in k-space along a first redundant spiral-in/out trajectory, and acquiring a second set of spiral interleaf data for each of the one or more spiral-in/out interleaves by performing a second sampling of each of the one or more locations in the k-space along a second redundant spiral-in/out trajectory, wherein the second redundant spiral-in/out trajectory corresponds to a time-reversed trajectory of the first redundant spiral-in/out trajectory. The method may yet further include combining the first set of spiral interleaf data and the second set of spiral interleaf data with an averaging operation such as to reduce artifacts.
Abstract translation: 系统，减少获取的磁共振成像数据中的非共振模糊的方法。 该方法包括：通过沿着第一冗余螺旋进/出轨迹对k空间中的一个或多个位置执行第一采样，获取一个或多个螺旋输入/输出交错中的每一个的第一组螺旋插入数据，以及 通过沿着第二冗余螺旋进/出轨迹执行所述k空间中的所述一个或多个位置中的每个位置的第二采样来获取所述一个或多个螺旋输入/输出交错中的每一个的第二组螺旋插入数据， 其中所述第二冗余螺旋进/出轨迹对应于所述第一冗余螺旋进/出轨迹的时间反转轨迹。 该方法还可以包括将第一组螺旋插入数据和第二组螺旋插值数据与平均化操作组合，以减少伪影。
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公开(公告)号：US11085980B2
公开(公告)日：2021-08-10
申请号：US15593894
申请日：2017-05-12
Applicant: UNIVERSITY OF VIRGINIA PATENT FOUNDATION , The Board of Trustees of the Leland Stanford Junior University
Inventor： Samuel W. Fielden , John P. Mugler, III , G. Wilson Miller, IV , Kim Butts Pauly , Craig H. Meyer
Abstract: In one aspect, in accordance with one embodiment, a method includes acquiring magnetic resonance (MR) data corresponding to bone tissue in an area of interest of a subject that is heated from the application of localized energy. The acquiring includes applying a three-dimensional (3D) ultra-short echo time (UTE) spiral acquisition sequence. The method also includes detecting, from the acquired magnetic resonance data, a change in MR response signal due to a change in at least one of relaxation rate and magnetization density caused by heating of the bone tissue; and determining, based at least in part on the change in the MR response signal, that the temperature of the bone tissue has changed.
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公开(公告)号：US20180292499A1
公开(公告)日：2018-10-11
申请号：US15947443
申请日：2018-04-06
Inventor： Craig H. Meyer , John P. Mugler, III , Samuel W. Fielden , Gudrun Ruyters , Berthold Kiefer , Josef Pfeuffer
IPC: G01R33/561 , G01R33/565 , G01R33/48 , G01R33/563
CPC classification number: G01R33/5615 , G01R33/243 , G01R33/4818 , G01R33/4824 , G01R33/56308 , G01R33/56518 , G01R33/56563
Abstract: In some aspects, the disclosed technology relates to magnetic field monitoring of spiral echo train imaging. In one embodiment, a method for spiral echo train imaging of an area of interest of a subject includes measuring k-space values and field dynamics corresponding to each echo of a spiral echo pulse train, using a dynamic field camera and a magnetic resonance imaging (MRI) system. The dynamic field camera is configured to measure characteristics of fields generated by the MRI system; the characteristics include at least one imperfection associated with the MRI system. The spiral echo pulse train corresponds to a spiral trajectory scan from the MRI system that obtains magnetic resonance imaging data using a pulse sequence which applies spiral gradients in-plane with through-plane phase encoding. The method also includes generating, based on the characteristics of the fields measured by the dynamic field camera and based on the obtained magnetic resonance imaging data, a model of the k-space trajectory corresponding to each echo of the spiral echo pulse train; and, based on the generated model of the k-space trajectory, reconstructing images that correspond to the area of interest and that are compensated for the at least one imperfection associated with the MRI system.
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