公开(公告)号：US20230142283A1

公开(公告)日：2023-05-11

申请号：US17759175

申请日：2021-03-03

Applicant: University of Washington

Inventor： David BAKER ,  Matthew BICK ,  TJ BRUNETTE

IPC: G16B15/20 ,  G16B35/10 ,  C12N15/10 ,  C07K14/47 ,  C07K14/00

CPC classification number: G16B15/20 ,  G16B35/10 ,  C12N15/1068 ,  C07K14/47 ,  C07K14/001 ,  C07K2319/00

Abstract: Disclosed herein are junction polypeptides that can be used, for example, to join together protein building blocks via a rigid fusion to generate a wide range of protein shapes; fusion proteins comprising such junction polypeptides, polymers thereof, and methods for designing such junction polypeptides.

公开(公告)号：US20220213153A1

公开(公告)日：2022-07-07

申请号：US17564467

申请日：2021-12-29

Applicant: University of Washington ,  NEW YORK UNIVERSITY

Inventor： Yang HSIA ,  Rubul MOUT ,  Natasha EDMAN ,  Ivan VULOVIC ,  Una NATTERMANN ,  William H. SHEFFLER ,  TJ BRUNETTE ,  Young-Jun PARK ,  Asim BERA ,  Matthew BICK ,  Rachel REDLER ,  Damian EKIERT ,  Gira BHABHA ,  David VEESLER ,  David BAKER

IPC: C07K14/47 ,  A61K47/62

Abstract: The disclosure provides polypeptides as descried herein that including an amino acid sequence at least 50% identical to the amino acid sequence selected from the group consisting of SEQ ID NOS:1-46, oligomers of such polypeptides, methods for using such polypeptides and oligomers, and methods for designing such polypeptides and oligomers.