公开(公告)号：US20230053634A1

公开(公告)日：2023-02-23

申请号：US17810480

申请日：2022-07-01

Applicant: University of Washington ,  ABACUS BIOSCIENCE, INC.

Inventor： Edward A. CLARK ,  Che-Leung LAW ,  Deborah FULLER ,  Michael GALE

IPC: A61K39/29 ,  A61P31/20 ,  C07K16/28

Abstract: Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpre S1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof.

公开(公告)号：US20200345838A1

公开(公告)日：2020-11-05

申请号：US16764950

申请日：2018-11-15

Applicant: University of Washington

Inventor： Edward A. CLARK ,  Che-Leung LAW ,  Deborah FULLER ,  Michael GALE

IPC: A61K39/29 ,  A61P31/20 ,  C07K16/28

Abstract: Compositions including a CD180 binding ligand and a linked Hepatitis B antigen and their use are disclosed. The Hepatitis B antigen includes Hepatitis B virus pre-S1 and/or pre-S2 region of the HBV envelope protein (HBVpreS1/S2Ag), L-HBsAg, MHBsAg, S-HBsAg, or antigenic fragments or mutants thereof.