公开(公告)号：US11617887B2

公开(公告)日：2023-04-04

申请号：US16389823

申请日：2019-04-19

申请人： University of Washington ,  Seattle Children's Hospital

发明人： Rajesh P. N. Rao ,  Jeffrey G. Ojemann ,  Eberhard E. Fetz ,  Chet T. Moritz ,  Jeffrey Herron

IPC分类号： A61N1/00 ,  A61N1/36 ,  A61N1/05

摘要： Systems and methods for promoting neuroplasticity in a brain of a subject to improve and/or restore neural function are disclosed herein. One such method includes detecting residual movement and/or muscular activity in a limb of the subject, such as a paretic limb. The method further includes generating a stimulation pattern based on the detected movement and/or muscular activity, and stimulating the brain of the subject with the stimulation pattern. It is expected that delivering stimulation based on the detected residual movement and/or muscular activity of the limb will induce neuroplasticity for restoring neural function, such as control of the limb. A second method involves detecting brain signals and delivering contingent stimulation. A third method involves delivering pairs of successive stimulus patterns to two brain sites, controlled either by preprogrammed sequences or contingent on neural or muscular activity or movement.

公开(公告)号：US20190321639A1

公开(公告)日：2019-10-24

申请号：US16389823

申请日：2019-04-19

申请人： University of Washington

发明人： Rajesh P.N. Rao ,  Jeffrey G. Ojemann ,  Eberhard E. Fetz ,  Chet T. Moritz ,  Jeffrey Herron

IPC分类号： A61N1/36 ,  A61N1/05

摘要： Systems and methods for promoting neuroplasticity in a brain of a subject to improve and/or restore neural function are disclosed herein. One such method includes detecting residual movement and/or muscular activity in a limb of the subject, such as a paretic limb. The method further includes generating a stimulation pattern based on the detected movement and/or muscular activity, and stimulating the brain of the subject with the stimulation pattern. It is expected that delivering stimulation based on the detected residual movement and/or muscular activity of the limb will induce neuroplasticity for restoring neural function, such as control of the limb. A second method involves detecting brain signals and delivering contingent stimulation. A third method involves delivering pairs of successive stimulus patterns to two brain sites, controlled either by preprogrammed sequences or contingent on neural or muscular activity or movement.